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Fmoc-Tyr(tBu)-OH

CAS No.: 71989-38-3

Chemical Name:: Fmoc-Tyr(tBu)-OH

Synonyms: FMOC-TYR(TBU)-OH;FMOC-TYR(TBU);Fmoc-Tyr(otbu)-OH;Tyr(tBu);FMOC-L-TYR(TBU)-OH;FMOC-TYR(TRT)-OH;FMOC-TYR(BUT);FMOC-L-TYROSINE(O-T-BUTYL);FMOC-L-TYR(TBU)-OH(71989-38-3);(2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

CBNumber:: CB5854161

Molecular Formula:: C28H29NO5

Molecular Weight:: 459.53

MOL File:: 71989-38-3.mol

MSDS File:: SDS

Modify Date:: 2024/6/13 17:47:58

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Fmoc-Tyr(tBu)-OH Properties

Melting point	~150 °C (dec.)
alpha	-28 º (c=1, DMF)
Boiling point	658.2±55.0 °C(Predicted)
Density	1.218±0.06 g/cm3(Predicted)
refractive index	-30 ° (C=1, DMF)
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), DMF (Slightly), Methanol (Slightly)
pka	2.97±0.10(Predicted)
form	Powder
color	White
optical activity	[α]20/D 29±2°, c = 1% in DMF
BRN	4216652
InChIKey	JAUKCFULLJFBFN-VWLOTQADSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	71989-38-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-24/25

WGK Germany

HS Code

2924 29 70

NFPA 704

	1
2		0

Fmoc-Tyr(tBu)-OH price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	8.52020	Fmoc-Tyr(tBu)-OH Novabiochem?	71989-38-3	25G	₹6410	2022-06-14	Buy
Sigma-Aldrich(India)	8.52020	Fmoc-Tyr(tBu)-OH Novabiochem?	71989-38-3	100G	₹18580	2022-06-14	Buy
Sigma-Aldrich(India)	8.52020	Fmoc-Tyr(tBu)-OH Novabiochem?	71989-38-3	250G	₹35149.99	2022-06-14	Buy
Sigma-Aldrich(India)	8.52020	Fmoc-Tyr(tBu)-OH Novabiochem?	71989-38-3	1KG	₹116889.99	2022-06-14	Buy
Sigma-Aldrich(India)	47623	Fmoc-Tyr(tBu)-OH ≥98.0% (HPLC)	71989-38-3	10G	₹6083.65	2022-06-14	Buy

Product number	Packaging	Price	Buy
8.52020	25G	₹6410	Buy
8.52020	100G	₹18580	Buy
8.52020	250G	₹35149.99	Buy
8.52020	1KG	₹116889.99	Buy
47623	10G	₹6083.65	Buy

Fmoc-Tyr(tBu)-OH Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline powder; insoluble in water and petroleum ether, soluble in ethyl acetate, methanol and DMF; mp is 150-151°C; specific optical rotation [α] 20D + 5.2° (0.5-2.0mg/ml, ethyl acetate ), [α]20D-27.6° (0.5-2.0 mg/ml, DMF), [α]20D-6° (0.5-2.0 mg/ml, methanol).

Uses

Fmoc-O-tert-butyl-L-tyrosine belongs to L-tyrosine compounds. Its molecular structure contains a chiral center, so it can exist two enantiomers and has optical activity. Fmoc-Tyr(tBu)-OH is used in peptide synthesis as amino acid protection monomer.

Preparation

To obtain Fmoc-Tyr(tBu)-OH, the following steps are carried out:
Suspend O-tert-butyl-L-tyrosine in a solution of dioxane.
Conduct an acylation reaction with fluorenyl methaneoxycarbonyl azide.
After the reaction, extract the crude product with ethyl acetate under pH 9-10 conditions.
Purify the extracted product through recrystallization.
This process results in the final product, Fmoc-Tyr(tBu)-OH.

General Description

Fmoc-Tyr(tBu)-OH is the preferred tyrosine derivative for solid phase peptide synthesis by Fmoc protocols. Protecting the Tyr sidechain may not be essential in the synthesis of small peptides. If the phenolic functional group of tyrosine does become acylated during a coupling reaction, the subsequent treatment with piperdine to remove Fmoc-groups will also remove any acylation of the phenolic function. Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient, however, since none of the activated amino acids are used unproductively in acylating exposed tyrosine side-chains. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain.

Fmoc-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Fluorene 1,4-Dioxane O-tert-Butyl-L-tyrosine

Preparation Products

Oxytocin ANGIOTENSIN I, HUMAN ANGIOTENSIN II, HUMAN FMOC-O-BUTYL-L-TYROSINE N-HYDROXYSUCCINIMIDE ESTER

Fmoc-Tyr(tBu)-OH Suppliers

Global( 485)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TEADUS PHARMA PRIVATE LIMITED	+91-9740077663 +91-9740077663	Telangana, India	242	58	Inquiry
SV CHEM INTERMEDITES PRIVATE LIMITED	+91-9940629423 +91-9940629423	Tamil Nadu, India	202	58	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry
Globe Chemie	+91 (20) 3230-9500	New Delhi, India	294	50	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry

Supplier	Advantage
TEADUS PHARMA PRIVATE LIMITED	58
SV CHEM INTERMEDITES PRIVATE LIMITED	58
JSK Chemicals	58
Globe Chemie	50
CLEARSYNTH LABS LTD.	58
CHEMSWORTH	30
A.J Chemicals	58
Otto Chemie Pvt. Ltd.	58
TCI Chemicals (India) Pvt. Ltd.	58
Sisco Research Laboratories Pvt. Ltd.	58

Fmoc-Tyr(tBu)-OH Spectrum

Fmoc-O-tert-butyl-L-tyrosine(71989-38-3)¹HNMR

71989-38-3(Fmoc-Tyr(tBu)-OH)Related Search:

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Fmoc-Aib-OH Cyhalofop-butyl 9-Fluorenylmethyl chloroformate PYRAZOPHOS tert-Butyldimethylsilyl chloride

Methyl 4-tert-butylbenzoate tert-Butyl hydroperoxide Nalpha-Fmoc-L-tyrosine

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FMOC-L-TYROSINE (TBU) o-(tert-butyl)-n-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-tyrosine O-TERT-BUTYL-NALPHA-FMOC-L-TYROSINE N-FMOC-T-BUTYL-L-TYR N-FMOC-O-T-BUTYL-L-TYROSINE N-ALPHA-FMOC-O-T-BUTYL-L-TYROSINE NALPHA-FMOC-O-TERT-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE NALPHA-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-O-TERT-BUTYL-L-TYROSINE N-(9-FLUORENYLMETHOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE N-9-FLUORENYLMETHYLOXYCARBONYL-O-T-BUTYL-L-TYROSINE N-9-FLUORENYLMETHYLOXYCARBONYL-O-TERT-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-L-TYROSINE 9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-TYROSINE L-Tyrosine-UL-13C9, 15N-N-FMOC N-(9-FLUORENYLMETHOXYCARBONYL)-2-TERT-BUTYL-L-TYROSINE NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-L-tyrosine N-A-FMOC-O-T-BUTYL-L-TYROSINE FMOC-O-T-BUTYL-L-TYROSINE (FMOC-L-TYR(TBU)-OH) FMOC-O-TERT-BUTYL-L-TYROSINE 98+% N-tert-Butoxycarbonyl-O-(2-bromo-Cbz)-L-tyrosine L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER (13C9,15N) Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine Fmoc-O-tert-butyl-L-tyrosine≥ 99.7% (HPLC, Chiral purity) (9-fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine Fmoc-O-tert-butyl-L-tyrosine, N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine FMOC-L-TYR(O-T-BUTYL) FMOC-L-TYR(T-BU) 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid N-(9-Fluorenylmethoxycarbonyl)-o-tert-butyl-L-tyrosine ,98% 4-tert-Butoxy-Fmoc-Phe-OH N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyl-L-tyrosine N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyltyrosine O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)-L-tyrosine O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)tyrosine Fmoc-(O-terbutyl)Tyrosine Fmoc-O-tert-butyl-L- FMco-Tyr(tBu)-OH L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER O-tert-Butyl-Nalpha-Fmoc-L-tyrosine Nalpha-Fmoc-O-tert-butyl-L-tyrosine Fmoc-Tyr(tBu)-OH N^a-FMoc-O-tert-butyl-L-tyrosine, 98% Fmoc-Tyr(tBu)-OH >=98.0% (HPLC) FMOC-TYR(BUT)-OH FMOC-TYROSINE(TBU)-OH FMOC-O-T-BUTYL-L-TYROSINE FMOC-O-TERT-BUTYL-L-TYROSINE (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-(tert-butoxy)phenyl)propanoic acid (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(tBu)-OH Fomc-Tyrs( Fomc-Tyrs(tBu)-OH Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine> FMOC-TYR(TBU)-OH 100 G FMOC-TYR(TBU)-OH 25 G FMOC-TYR(TBU)-OH 250 G L-Tyrosine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- Fmoc-O-tert-butyl-L-tyrosine USP/EP/BP