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L-THREO-DIHYDROSPHINGOSINE

L-THREO-DIHYDROSPHINGOSINE Structure
CAS No.
15639-50-6
Chemical Name:
L-THREO-DIHYDROSPHINGOSINE
Synonyms
SAFINGOL;L-threo-dihydrospingosine;L-THREO-DIHYDROSPHINGOSINE;L-THREO-SPHINGANINE, C18 CHAIN;L-threo-dihydrosphingosine (d18:0);L-threo-Dihydrosphingosine (Safingol);Safingol - CAS 15639-50-6 - Calbiochem;1,3-Octadecanediol, 2-amino-, (2S,3S)-;L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL
CBNumber:
CB1192274
Molecular Formula:
C18H39NO2
Molecular Weight:
301.51
MOL File:
15639-50-6.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:17
Request For Quotation

L-THREO-DIHYDROSPHINGOSINE Properties

Melting point 126-128 °C
Boiling point 446.2±25.0 °C(Predicted)
Density 0.927±0.06 g/cm3(Predicted)
Flash point 110 °C
storage temp. -20°C
solubility ≤0.25mg/ml in ethanol
form White solid
pka 12.57±0.45(Predicted)

SAFETY

Risk and Safety Statements

WGK Germany  3

L-THREO-DIHYDROSPHINGOSINE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D4681 L-threo-Dihydrosphingosine ≥95% (TLC) 15639-50-6 1MG ₹21628.35 2022-06-14 Buy
Sigma-Aldrich(India) 559300 Safingol - CAS 15639-50-6 - Calbiochem A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding doma 15639-50-6 1MG ₹19050 2022-06-14 Buy
Product number Packaging Price Buy
D4681 1MG ₹21628.35 Buy
559300 1MG ₹19050 Buy

L-THREO-DIHYDROSPHINGOSINE Chemical Properties,Uses,Production

Uses

L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.

General Description

A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 μM and 31 μM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.

Biochem/physiol Actions

Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.

L-THREO-DIHYDROSPHINGOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

L-THREO-DIHYDROSPHINGOSINE Suppliers

Global( 69)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Alfa Chemistry +1-5166625404 United States 21317 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9155 58 Inquiry
SHANGHAI ZZBIO CO., LTD. 19921389125 19921389125 China 12065 58 Inquiry
Alfa Chemistry 1-516-6625404 United States 9171 60 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Supplier Advantage
Career Henan Chemica Co 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Alfa Chemistry 58
GIHI CHEMICALS CO.,LIMITED 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
SHANGHAI ZZBIO CO., LTD. 58
Alfa Chemistry 60
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81

15639-50-6(L-THREO-DIHYDROSPHINGOSINE)Related Search:

D-THREO-DIHYDROSPHINGOSINE DL-THREO-DIHYDROSPHINGOSINE N-DODECANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE,N-C12-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT C6 NBD-L-THREO-DIHYDROSPHINGOSINE DIHYDROSPHINGOSINE, L-THREO [4,5-3H]
C12 NBD-L-THREO-DIHYDROSPHINGOSINE N-C6-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT,N-HEXANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE Cedefingol L-THREO-DIHYDROSPHINGOSINE
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SAFINGOL L-THREO-SPHINGANINE, C18 CHAIN L-THREO-DIHYDROSPHINGOSINE L-threo-dihydrospingosine L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL L-threo-dihydrosphingosine (d18:0) 1,3-Octadecanediol, 2-amino-, (2S,3S)- Safingol - CAS 15639-50-6 - Calbiochem L-threo-Dihydrosphingosine (Safingol) 15639-50-6 Biochemicals and Reagents BioChemical Lipids Sphingolipids Sphinganines Sphingoid bases