N4-Acetylcytidine
- CAS No.
- 3768-18-1
- Chemical Name:
- N4-Acetylcytidine
- Synonyms
- N-Acetylcytidine;Ac-rC;Acetylcytidine;rC(Ac);N4-Ac-Cr;N4-Ac-rC;ACETYL CYTOSINE;n-acetyl-cytidin;4-Acetylcytidine;N4-ACETYLCYTIDINE
- CBNumber:
- CB1207392
- Molecular Formula:
- C11H15N3O6
- Molecular Weight:
- 285.25
- MOL File:
- 3768-18-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/20 11:41:24
| Melting point | 199 °C (dec.)(lit.) |
|---|---|
| Density | 1.72±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| pka | 10.21±0.20(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
| PH | ＜1.5 |
| λmax | 247，297 (pH 7) |
| CAS DataBase Reference | 3768-18-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Cytidine, n-acetyl-(3768-18-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 36-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
N4-Acetylcytidine Chemical Properties,Uses,Production
Description
N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. tRNA has been shown to be excreted in abnormal amounts in the urine of cancer patients. tRNA from neoplastic tissue had a much more rapid turnover rate than the tRNA from the corresponding normal tissue. Evidence indicates that methylation of tRNA occurs only after synthesis of the intact macromolecule. Because there are no specific enzyme systems to incorporate the modified nucleosides into the macromolecular nucleic acid, these nucleosides once released in the process of tRNA turnover cannot be reutilized, nor are they further degraded, but are excreted in urine.
N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.
Uses
N4-Acetylcytidine (cas# 3768-18-1) is a nucleotide-derived metabolite used as biomarkers for diagnosis of inflammation-related diseases.
Definition
ChEBI: N(4)-acetylcytidine is cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It has a role as a metabolite. It is a member of cytidines, a member of acetamides and a secondary carboxamide.
N4-Acetylcytidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Vagmine Bio | 08068970605Ext 713 | Hyderabad, India | 13 | 58 | Inquiry |
| Zhejiang Hengkang Pharmaceutical Co., Ltd. | +86-576-83372028 +86-18868723926 | China | 119 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19805 | 58 | Inquiry |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | China | 299 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29858 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 8497 | 58 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 19825 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | China | 6383 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
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