N-Methylleukotriene C4
![N-Methylleukotriene C4 Structure](CAS/20181012/GIF/131391-65-6.gif)
- CAS No.
- 131391-65-6
- Chemical Name:
- N-Methylleukotriene C4
- Synonyms
- NMLTC4;N-METHYL LTC4;N-Methylleukotriene C4;FPLBRCJNODNRQZ-UYCXAPQFSA-N;N methyl Leukotriene C4,N-methyl Leukotriene C-4,Nmethyl Leukotriene C4;Glycine, N-methyl-L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-;N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]-N-methylglycine
- CBNumber:
- CB12192012
- Molecular Formula:
- C31H49N3O9S
- Molecular Weight:
- 639.81
- MOL File:
- 131391-65-6.mol
- Modify Date:
- 2023/6/8 9:03:09
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H319 | |||||||||
Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
NFPA 704 |
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N-Methylleukotriene C4 Chemical Properties,Uses,Production
Uses
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
N-Methylleukotriene C4 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
United States Biological | 1-800-520-3011 | United States | 6106 | 58 | Inquiry |
Shanghai Benrui Biotechnology Co., Ltd. | 13917534498 | CHINA | 1472 | 58 | Inquiry |
Morning Student Science and Technology (Guangzhou) Co., Ltd. | 020-36048871 13760856740 | CHINA | 6618 | 58 | Inquiry |
Shanghai Yaoyun Biological Technology Co., Ltd. | 400-002-6926 400-002-6926 | CHINA | 6852 | 58 | Inquiry |
Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
Beijing Shengke Boyuan Biotechnology Co., Ltd. | 010-62968438 | CHINA | 6011 | 58 | Inquiry |
Beijing Zhijie Fangyuan Technology Co., Ltd. | 010-82897201 15810200961 | CHINA | 6984 | 58 | Inquiry |
Boao Pike | 010-57798038 15652371397 | CHINA | 6629 | 58 | Inquiry |
Shenzhen Xinbosheng Biological Technology Co., Ltd. | 0755-26755892 | CHINA | 6164 | 58 | Inquiry |
Beijing Bolide Biotechnology Co., Ltd. | 010-51653916 | CHINA | 6172 | 58 | Inquiry |