Pirenzepine hydrochloride
![Pirenzepine hydrochloride Structure](CAS/GIF/29868-97-1.gif)
- CAS No.
- 29868-97-1
- Chemical Name:
- Pirenzepine hydrochloride
- Synonyms
- Tabe;Maghen;Leblon;l-s519;Ulcosan;Renzepin;Gasteril;ls519cl2;Bisvanil;Gastricur
- CBNumber:
- CB1245572
- Molecular Formula:
- C19H22ClN5O2
- Molecular Weight:
- 387.87
- MOL File:
- 29868-97-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/18 13:26:42
Melting point | 248-250°C |
---|---|
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Water Solubility | Soluble to 100 mM in water |
Sensitive | Hygroscopic |
CAS DataBase Reference | 29868-97-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H317-H402 | |||||||||
Precautionary statements | P501-P261-P273-P272-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313-P301+P312+P330 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | UU7883000 | |||||||||
HS Code | 2933.99.7500 | |||||||||
Toxicity | dog,LD50,intravenous,62500ug/kg (62.5mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988. | |||||||||
NFPA 704 |
|
Pirenzepine hydrochloride price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | P7412 | Pirenzepine dihydrochloride ≥98% (TLC), powder | 29868-97-1 | 500MG | ₹10705.93 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | P7412 | Pirenzepine dihydrochloride ≥98% (TLC), powder | 29868-97-1 | 1G | ₹18987.05 | 2022-06-14 | Buy |
TCI Chemicals (India) | P2457 | Pirenzepine Dihydrochloride | 29868-97-1 | 200MG | ₹3200 | 2022-05-26 | Buy |
TCI Chemicals (India) | P2457 | Pirenzepine Dihydrochloride | 29868-97-1 | 1G | ₹9700 | 2022-05-26 | Buy |
Pirenzepine hydrochloride Chemical Properties,Uses,Production
Description
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.
Chemical Properties
Solid
General Description
Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.
Pirenzepine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21668 | 55 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29892 | 58 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
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