Methylphenidate hydrochloride
![Methylphenidate hydrochloride Structure](CAS/GIF/298-59-9.gif)
- CAS No.
- 298-59-9
- Chemical Name:
- Methylphenidate hydrochloride
- Synonyms
- METHYLPHENIDATE HCL;Concerta;methylphenidate hydrochloride methanol*solution;Equasym;Metadate;Centedin;Centedrin;Centedrine;NSC 169868;Ciba 4311b
- CBNumber:
- CB0188559
- Molecular Formula:
- C14H20ClNO2
- Molecular Weight:
- 269.77
- MOL File:
- 298-59-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/17 16:57:51
Melting point | 196-198?C |
---|---|
Flash point | 9℃ |
storage temp. | Store at RT |
solubility | Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
form | Powder |
pka | 8.9(at 25℃) |
Water Solubility | Soluble to 50 mM in water and to 100 mM in ethanol |
BCS Class | 2 |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates. |
InChI | InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H |
InChIKey | JUMYIBMBTDDLNG-UHFFFAOYSA-N |
SMILES | C(C(=O)OC)(C1NCCCC1)C1C=CC=CC=1.Cl |
CAS DataBase Reference | 298-59-9(CAS DataBase Reference) |
EPA Substance Registry System | Methylphenidate hydrochloride (298-59-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H302-H334 |
Precautionary statements | P261-P264-P270-P284-P301+P312-P501 |
Hazard Codes | Xn,T,F |
Risk Statements | 22-42-39/23/24/25-23/24/25-11 |
Safety Statements | 22-26-36-45-36/37-16 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | TM3850000 |
HazardClass | 6.1(b) |
PackingGroup | III |
Toxicity | LD50 orally in mice: 190 mg/kg (Greenblatt, Osterberg) |
Methylphenidate hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methyl phenidate exhibits the pharmacologically usually desired effects.
General Description
Odorless white crystalline powder. Metallic taste. Solutions are acid to litmus. Absence of general acid/base catalysis.
Air & Water Reactions
Water soluble.
Reactivity Profile
Methylphenidate hydrochloride is incompatible with alkalis and solutions of barbiturates . Undergoes typical ester hydrolysis in aqueous solutions at 176°F.
Fire Hazard
Flash point data for Methylphenidate hydrochloride are not available; however, Methylphenidate hydrochloride is probably combustible.
Biological Activity
Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo .
Methylphenidate hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
Centaur Pharmaceuticals Pvt Ltd | +912266499100 | Mumbai, India | 33 | 58 | Inquiry |
Malladi Drugs AND Pharmaceuticals Limited | +91-9004653310 +91-9003056437 | Tamil Nadu, India | 69 | 58 | Inquiry |
Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
ZCL Chemicals Ltd | +91-2261539999 +91-2261539999 | Maharashtra, India | 53 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Cohance Lifesciences (Previously RA Chem Pharma Ltd) | +91-4044758595 +91-4044758595 | Telangana, India | 47 | 58 | Inquiry |
OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
IPCA Laboratories Limited | +91 (22) 6210 5000 | New Delhi, India | 56 | 58 | Inquiry |
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