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ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >Fluorobenzaldehyde series >1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Structure
CAS No.
1125812-58-9
Chemical Name:
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
Synonyms
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one;afoxolaner-002;afoxolaner Impurity 6;1-[3-Chloro-5-trifluoromethylphenyl;2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone;3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone;3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone;1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone;Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-;1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001：2015 REACH
CBNumber:
CB12514588
Molecular Formula:
C9H3ClF6O
Molecular Weight:
276.56
MOL File:
1125812-58-9.mol
MSDS File:
SDS
Modify Date:
2023/6/9 13:57:52
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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Properties

Boiling point 203℃
Density 1.512
Flash point 77℃
storage temp. 2-8°C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS05
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Chemical Properties,Uses,Production

Uses

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_1125812-58-9
Cool the solution containing compound III (74.4g, 0.255mol containing compound III) to -100, and add 120g of sulfuric acid with a mass fraction of 92.5% to the above system while keeping the temperature below 0. After acidification, continue to react and keep for 1.5h, and then add 126.7g of 33% sodium nitrite aqueous solution (containing diazotizing reagent sodium nitrite 0.612mol) into the system uniformly within 2h, and keep the temperature at 0 The following reaction is carried out for 2 hours, and the system is heated to room temperature after full reaction, 111.1 g of 50% hypophosphorous acid and 0.67 g of cuprous oxide are added, and the reaction is stirred for 2 hours while keeping temperature. After the reaction is over, stand to separate the layers, and wash the organic layer with a 5% sodium bicarbonate aqueous solution, dry with anhydrous magnesium sulfate, and rectify to obtain a clear and transparent oily liquid 1-[3-chloro-5-(trifluoromethyl) (Yl)phenyl]-2,2,2-trifluoroethanone 66.9, content 99.5%, yield 87.2%.

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Preparation Products And Raw materials

Raw materials

3-CHLORO-5-(TRIFLUOROMETHYL)BENZOYL CHLORIDE 3 - chloro - 5 - (trifluoroMethyl) benzene iodine 3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Methyl 3-chloro-5-(trifluoroMethyl)benzoate 3-Bromo-5-Chlorobenzotrifluoride
2,2-Dimethyl-N-(4-trifluoromethyl-phenyl)-propionamid Ethyl trifluoroacetate Methyl trifluoroacetate 4-Aminobenzotrifluoride
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Preparation Products

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Suppliers

Global( 134)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Lavender lab +91-9503104600 +91-9503104600 Maharashtra, India 56 58 Inquiry
COMBIOTECH PVT LTD +91-9980822499 +91-9980822499 Karnataka, India 69 58 Inquiry
Sanovi Pharmaceuticals Pvt Ltd +91-9900284769 +91-9900284769 Karnataka, India 42 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29820 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10297 58 Inquiry
ENBRIDGE PHARMTECH CO., LTD. +8613812269233 China 302 58 Inquiry
Masteam Bio-tech Co., Ltd. +86-15200345168 +86-15200345168 CHINA 153 58 Inquiry
Supplier Advantage
Lavender lab 58
COMBIOTECH PVT LTD 58
Sanovi Pharmaceuticals Pvt Ltd 58
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Fuxin Pharmaceutical 58
ENBRIDGE PHARMTECH CO., LTD. 58
Masteam Bio-tech Co., Ltd. 58
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone 2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone 3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro- 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one (Afoxolaner intermediate） 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001：2015 REACH afoxolaner-002 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one afoxolaner Impurity 6 1-[3-Chloro-5-trifluoromethylphenyl 1125812-58-9 1123812-58-9