3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS No.
- 53985-49-2
- Chemical Name:
- 3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Synonyms
- 3-Chloro-5-carboxybenzotrifluoride;3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID;Benzoic acid, 3-chloro-5-(trifluoromethyl)-;3-Carboxy-5-chlorobenzotrifluoride, 5-Chloro-alpha,alpha,alpha-trifluoro-m-toluic acid
- CBNumber:
- CB4435008
- Molecular Formula:
- C8H4ClF3O2
- Molecular Weight:
- 224.56
- MOL File:
- 53985-49-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/28 13:07:02
| Melting point | 98-101℃ |
|---|---|
| Boiling point | 263℃ |
| Density | 1.523 |
| Flash point | 113℃ |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Soluble in water. |
| CAS DataBase Reference | 53985-49-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Chemical Properties,Uses,Production
Uses
2-Chloro-5-(trifluoromethyl)benzoic acid may be used as surrogate standard to investigate the exposure and home contamination in urine and hand wipe samples collected from farmers.
Synthesis
A solution of tBuONO (35.2 g) and CuCl (38.6 g) in CH3CN (375 mL) was warmed to 45-50° C. The compound (50.0 g) obtained in step 2 was added slowly while cooling the reaction mixture to maintain 45-50° C. After stirring at 50° C. for 30 min, the mixture was cooled to 10° C. 6N Hydrochloric acid (250 mL) was added and the mixture was stirred for 10 min. The resultant product was extracted twice with ethyl acetate. The organic layer was-washed with 10% aqueous citric acid solution and water and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 10→25% ethyl acetate/hexane) to give 3-chloro-5-(trifluoromethyl)benzoic acid (33.1 g, 60%) as a white powder.
3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20361 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | China | 5791 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| WinWin Chemical CO., Limited | +86-0577-64498589 +8615325081899 | China | 14198 | 58 | Inquiry |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | China | 5660 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
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