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4-chloro-7-Methoxyquinoline-6-carboxaMide

CAS No.: 417721-36-9

Chemical Name:: 4-chloro-7-Methoxyquinoline-6-carboxaMide

Synonyms: lenvaint-E;synthesis-024;synthesis-1-014;ine-6-carboxamide;oro-7-methoxyquinoL;Lenvatinib Impurity b;Lenvatinib Impurity 50;Lenvatinib Impurity LFS-B;4-chloro-7-Methoxy-6-QuinolinecarboxaMide;4-chloro-7-Methoxyquinoline-6-carboxaMide

CBNumber:: CB12596687

Molecular Formula:: C11H9ClN2O2

Molecular Weight:: 236.65

MOL File:: 417721-36-9.mol

Modify Date:: 2024/6/18 13:26:42

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4-chloro-7-Methoxyquinoline-6-carboxaMide Properties

Melting point	>205°C (dec.)
Boiling point	426.7±45.0 °C(Predicted)
Density	1.380±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	15.28±0.30(Predicted)
form	Solid
color	Off-White to Light Beige
InChI	InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
InChIKey	ZBTVNIDMGKZSGC-UHFFFAOYSA-N
SMILES	N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference	417721-36-9

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933499090

4-chloro-7-Methoxyquinoline-6-carboxaMide Chemical Properties,Uses,Production

Description

4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).

4-chloro-7-Methoxyquinoline-6-carboxaMide Preparation Products And Raw materials

Raw materials

Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate 4-chloro-7-Methoxyquinoline-6-carbonitrile

Preparation Products

4-chloro-7-Methoxyquinoline-6-carboxaMide Suppliers

Global( 348)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Accrete Pharmaceuticals Private Limited	+91-9246370012 +91-9246370012	Hyderabad, India	24	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SyncoZymes (Shanghai) Co., Ltd.,	+86-021-68187180-811 +86-13681683526	China	188	58	Inquiry
Beijing Mediking Biopharm Co., Ltd	+undefined15901403431	China	150	58	Inquiry
Hebei Guanlang Biotechnology Co,.LTD	+86-19930503253; +8619930503252	China	5904	58	Inquiry
Hebei Duling International Trade Co. LTD	+8617333973358	China	15437	58	Inquiry
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	China	2503	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry

Supplier	Advantage
Accrete Pharmaceuticals Private Limited	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SyncoZymes (Shanghai) Co., Ltd.,	58
Beijing Mediking Biopharm Co., Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58
Hebei Duling International Trade Co. LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

4-chloro-7-Methoxyquinoline-6-carboxaMide Spectrum

4-chloro-7-Methoxyquinoline-6-carboxaMide(417721-36-9)¹HNMR

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6-QuinolinecarboxaMide, 4-chloro-7-Methoxy- 4-chloro-7-Methoxyquinoline-6-carboxaMide 4-chloro-7-Methoxy-6-QuinolinecarboxaMide Lenvatinib Impurity b 4-Chloro-7-methoxy-quinoline-6-carboxylic acid amide 4-Chloro-7-methoxyquinazoline-6-carboxamide Lenvatinib Impurity LFS-B synthesis-024 lenvaint-E ine-6-carboxamide oro-7-methoxyquinoL synthesis-1-014 Lenvatinib Impurity 50 417721-36-9 477721-36-9 Intermediate 417721-36-9