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5-chloro-2,3-diphenylpyrazine

5-chloro-2,3-diphenylpyrazine Structure
CAS No.
41270-66-0
Chemical Name:
5-chloro-2,3-diphenylpyrazine
Synonyms
Selexipag Impurity 31;2-Chloro-5,6-diphenylpyrazine;Pyrazine, 5-chloro-2,3-diphenyl-;chloro-2,3-diphenylpyrazine (Selexipag Intermediate)
CBNumber:
CB12676877
Molecular Formula:
C16H11ClN2
Molecular Weight:
266.72
MOL File:
41270-66-0.mol
MSDS File:
SDS
Modify Date:
2024/8/1 10:00:58

5-chloro-2,3-diphenylpyrazine Properties

Melting point 126-128℃ (methanol )
Boiling point 145°C/0.001mmHg(lit.)
Density 1?+-.0.06 g/cm3(Predicted)
pka -2.16±0.10(Predicted)
form powder to crystal
color White to Orange to Green
InChI InChI=1S/C16H11ClN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H
InChIKey VUGNCPVAXWZTOL-UHFFFAOYSA-N
SMILES C1(C2=CC=CC=C2)=NC=C(Cl)N=C1C1=CC=CC=C1
CAS DataBase Reference 41270-66-0

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H413
Precautionary statements  P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2933.99.5300
NFPA 704
0
2 0

5-chloro-2,3-diphenylpyrazine price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) C3205 5-Chloro-2,3-diphenylpyrazine min. 98.0 % 41270-66-0 1G ₹7800 2022-05-26 Buy
TCI Chemicals (India) C3205 5-Chloro-2,3-diphenylpyrazine min. 98.0 % 41270-66-0 5G ₹17500 2022-05-26 Buy
Product number Packaging Price Buy
C3205 1G ₹7800 Buy
C3205 5G ₹17500 Buy

5-chloro-2,3-diphenylpyrazine Chemical Properties,Uses,Production

Uses

2-Chloro-5,6-diphenylpyrazine is a diphenylpyrazine derivative used in a study to determine a novel class of prostacyclin receptor agonists.

Synthesis

50 gm of 2-hydroxy-5,6-diphenylpyrazine obtained was treated with 250 ml of POCI3 and then heated the reaction mixture at 100-110 °C with stirring for 5-6 hrs. The reaction mixture was cooled to room temperature and poured in 1000 ml of ice water at 0-5 °C and maintained with stirring for 60 minutes. The solid obtained was filtered, washed with water and dried to obtain 41.3 gm of 5-chloro-2,3-diphenylpyrazine. Yield: 77.00 percent.

5-chloro-2,3-diphenylpyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 184)Suppliers
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VASUDHA PHARMA CHEM LIMITED +91-91-4044763666 +91-9396659284 Telangana, India 102 58 Inquiry
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2-Chloro-5,6-diphenylpyrazine Pyrazine, 5-chloro-2,3-diphenyl- Selexipag Impurity 31 chloro-2,3-diphenylpyrazine (Selexipag Intermediate) 41270-66-0 Selexipag intermediate