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SELEXIPAG interMediate

CAS No.: 475086-75-0

Chemical Name:: SELEXIPAG interMediate

Synonyms: 4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;SELEXIPAH INT;Selexipag Impurity 32;Selexipag internate 1;SELEXIPAG interMediate;Selexipag intermediates;Diphenyl pyrazine impurity;4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol;4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol;-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol

CBNumber:: CB42728841

Molecular Formula:: C23H27N3O

Molecular Weight:: 361.48

MOL File:: 475086-75-0.mol

MSDS File:: SDS

Modify Date:: 2024/3/22 21:24:34

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SELEXIPAG interMediate Properties

Melting point	68 - 71°C
Boiling point	514.4±50.0 °C(Predicted)
Density	1.112±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	15.05±0.10(Predicted)
form	Solid
color	Pale Yellow to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

SELEXIPAG interMediate Chemical Properties,Uses,Production

Uses

4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Application

Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent.

SELEXIPAG interMediate Preparation Products And Raw materials

Raw materials

5-chloro-2,3-diphenylpyrazine 4-(Isopropylamino)butanol

Preparation Products

SELEXIPAG interMediate Suppliers

Global( 125)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
VSK LIFE SCIENCES PRIVATE LIMITED	+91 7995529789	Hyderabad, India	220	58	Inquiry
Viyash Life Sciences Pvt Ltd	+91-4023635052 +91-4023635052	Telangana, India	213	58	Inquiry
Aventus Labs	+91-7021872517 +91-9324342304	Maharashtra, India	168	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Seasons Biotechnology Co., Ltd.	+86-0576-89232655 +86-13566878689	China	47	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20235	58	Inquiry
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	China	29730	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	China	19805	58	Inquiry

Supplier	Advantage
VSK LIFE SCIENCES PRIVATE LIMITED	58
Viyash Life Sciences Pvt Ltd	58
Aventus Labs	58
Lakshmi Farmachem	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Seasons Biotechnology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

475086-75-0(SELEXIPAG interMediate)Related Search:

5-chloro-2,3-diphenylpyrazine ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester ) [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID 2,3-DIPHENYLPYRAZINE Bromoacetic acid

2-T-BUTYL GLYCOLATE 4-(Isopropylamino)butanol 5,6-DIPHENYLPYRAZIN-2-OL N-(methylsulfonyl)glycine 2,3-Dichloro-5,6-diphenylpyrazine

Cefepime Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]- 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl- 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]- Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester

Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)- Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-

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SELEXIPAG interMediate Selexipag intermediates 1-Butanol, 4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]- 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]- 4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol -[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol Selexipag Impurity AQ: What is Selexipag Impurity A Q: What is the CAS Number of Selexipag Impurity A Q: What is the storage condition of Selexipag Impurity A Q: What are the applications of Selexipag Impurity A Selexipag internate 1 SELEXIPAH INT Selexipag Impurity 32 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol 4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol 4-[(5,6-Diphenylpyrazin-2-yl)(1-methylethyl)amino]-1-butanol Diphenyl pyrazine impurity 4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol (Isopropylamine Impurity) 475086-75-0 non-prostanoid prostacyclin (PGI2) receptor agonist selexipag