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GSK 2330672

GSK 2330672 Structure
CAS No.
1345982-69-5
Chemical Name:
GSK 2330672
Synonyms
linerixibat;CS-2639;Iinerixibat;GSK 2330672;Iinerixibat (GSK2330672);linerixibat (GSK2330672);GSK 2330672; GSK-2330672;3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid;Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-;3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
CBNumber:
CB12716247
Molecular Formula:
C28H38N2O7S
Molecular Weight:
546.68
MOL File:
1345982-69-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:00
Request For Quotation

GSK 2330672 Properties

Boiling point 730.8±60.0 °C(Predicted)
Density 1.218±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form A crystalline solid
pka 3.27±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H401-H411
Precautionary statements  P261-P264-P270-P271-P273-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P391-P403+P233-P405-P501
NFPA 704
0
2 0

GSK 2330672 Chemical Properties,Uses,Production

Description

GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.

GSK 2330672 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK 2330672 Suppliers

Global( 64)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 4695 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Guangzhou Weijia Technology Co., Ltd. 020-84224925 18300190102 CHINA 6748 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58
Guangzhou Weijia Technology Co., Ltd. 58

1345982-69-5(GSK 2330672)Related Search:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine
GSK 2801 GSK2636771 GSK2879552 GSK2795039 GSK2838232
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GSK 2330672 GSK 2330672; GSK-2330672 3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)- CS-2639 Iinerixibat Iinerixibat (GSK2330672) linerixibat type-2,PBC,lipid-lowering,solubility,nonabsorbable,GSK-2330672,Inhibitor,Primary,diabetes,GSK 2330672,Cholangitis,inhibit,Linerixibat,aqueous,Biliary,ASBT linerixibat (GSK2330672) 3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid 1345982-69-5