GSK-2256098

CAS No.: 1224887-10-8

Chemical Name:: GSK-2256098

Synonyms: CS-2424;GTPL7939;GSK-2256099;GSK-2256098;GSK-2256098, GTPL7939;GSK-2256098;GSK 2256098;FAK inhibitor GS2256098;2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide;2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide;Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-

CBNumber:: CB83044319

Molecular Formula:: C20H23ClN6O2

Molecular Weight:: 414.89

MOL File:: 1224887-10-8.mol

Modify Date:: 2024/7/2 8:55:24

Request For Quotation

GSK-2256098 Properties

Density	1.32±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM) Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM)
form	A crystalline solid
pka	5.24±0.10(Predicted)
color	White to khaki
InChI	InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey	BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES	C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P280-P305+P351+P338-P310

NFPA 704

	0
2		0

GSK-2256098 Chemical Properties,Uses,Production

Description

GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC₅₀s = 15, 8.5, and 12 nM, respectively). It induces apoptosis and increases PARP levels, decreases viability (IC₅₀ = 25 μM), and inhibits colony formation in L3.6P1 cells. GSK2256098 (75 mg/kg per day) also leads to lower tumor weight and fewer metastases in the Ishikawa orthotopic mouse model of uterine cancer.

Uses

GSK 2256098 is FAK inhibitor. It can be used in biological study of molecular pathways: endothelial cell FAK-?A target for cancer treatment.

GSK-2256098 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-2256098 Suppliers

Global( 105)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23555	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9640	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58

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GSK-2256098 2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide GTPL7939 Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy- 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide CS-2424 FAK inhibitor GS2256098 GSK-2256098;GSK 2256098 GSK-2256099 GSK-2256098, GTPL7939 1224887-10-8 Inhibitors APIs