1,2,4-Tributylphosphorotrithioate

1,2,4-Tributylphosphorotrithioate Properties

Melting point	<-25°
Boiling point	bp0.3 150°; bp4 166.5°
Density	d204 1.0552
refractive index	nD20 1.534
storage temp.	0-6°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Colourless
CAS DataBase Reference	78-48-8
NIST Chemistry Reference	S,s,s-tributyl phosphorotrithioate(78-48-8)
EPA Substance Registry System	Tribufos (78-48-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS09
Signal word	Danger
Hazard statements	H301-H310-H410
Precautionary statements	P273-P280-P301+P310-P302+P350-P310-P501
Hazard Codes	T,N
Risk Statements	24/25-50/53
Safety Statements	36/37-45-61-60
RIDADR	UN 2811
RTECS	TG5425000
HazardClass	6.1(a)
PackingGroup	II
Toxicity	LD50 in male, female rats (mg/kg): 233, 150 orally; 360, 168 dermally (Gaines)

1,2,4-Tributylphosphorotrithioate price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SAB1302859	ANTI-DEF (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	78-48-8	400μL	₹47796.6	2022-06-14	Buy

Product number	Packaging	Price	Buy
SAB1302859	400μL	₹47796.6	Buy

1,2,4-Tributylphosphorotrithioate Chemical Properties,Uses,Production

Description

DEF is a cholinesterase-inhibiting organophosphorus pesticide compound used as a cotton defoliant that was registered in 1960.DEF is a colorless to pale-yellow transparent liquid with a skunk-like odor.It is completely miscible with n-hexane, dichloromethane, toluene, and 2-propanol and has an octanol–water partition coefficient of 3.31×10⁵ at 25°C. DEF toxicity is primarily attributed to inhibition of various esterases, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), neuropathic target esterase (NTE), and carboxylesterase, resulting in increased accumulation of endogenous acetylcholine (ACh) in cholinergic nerve terminals and related effector organs.

Chemical Properties

Tribufos is a colorless to yellow liquid. Tribufos is relatively stable to acids and heat and is hydrolyzed slowly under alkaline conditions. Tribufos has a mercaptan or skunk-like odor. Tribufos has a mercaptan or skunk-like odor. Practically insoluble in water (2.3×10^-4 g/ 100 mL); completely miscible in dichloromethane, n-hexane, 2-propanol, toluene.

Uses

1,2,4-Tributylphosphorotrithioate is a defoliant for cotton.

General Description

Colorless to pale yellow liquid with mercaptan-like odor. Insoluble in water; soluble in aliphatic, aromatic, and chlorinated hydrocarbons.. Used as a growth regulator.

Air & Water Reactions

Insoluble in water. Hydrolyzed slowly by alkaline conditions.

Reactivity Profile

An organophosphate derivative. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Cholinesterase inhibitor.

Agricultural Uses

Herbicide, Defoliant, Plant growth regulator: Tribufos is an organophosphate defoliant used for cotton crops. It is specifically used to defoliate cotton in preparation for machine harvesting. It was first registered in the United States in 1961. Not approved for use in EU countries . Registered for use in the U.S.

Trade name

B-1776®; BUTIFOS®; BUTIPHOS®[C]; CHEMAGRO® 1776; CHEMAGRO® B-1776; DE- GREEN®; DEF®; DEF DEFOLIANT®; DELEAFDEFOLIANT®; EASY OFF®-D; E-Z-OFF® D; FOLEX® 6EC FOS-FALL® A; ORTHO® phosphate defoliant

Safety Profile

A poison by ingestion, skin contact, and intraperitoneal routes. Experimental reproductive effects. Animal experiments show an anti-cholinesterase effect. When heated to decomposition it emits toxic fumes of PO, and SO,. See also PARATHION, PHOSPHATES, ESTERS, and SULFATES.

Carcinogenicity

No carcinogenic effects occurred when rats were given diets with 0, 4, 40, or 320 ppm tribufos (equivalent to 0.0, 0.2, 1.8, and 16.8 mg/kg/day in males and 0.0, 0.2, 2.3, and 21.1 mg/kg/day in females, respectively) for 2 years .
In a carcinogenicity study, mice were fed diets containing tribufos at doses of 0, 10, 50, or 250 ppm (equivalent to 0.0, 1.64, 8.28, or 48.02 mg/kg/day in males and 0.0, 2.08, 11.14, or 63.4 mg/kg/day in females) for 90 weeks . Carcinogenic effects were evident at 250 ppm (48.02 mg/kg/day in males and 63.4 mg/kg/day in females). Males exhibited a statistically significant increase in hemangiosarcomas and adenocarcinomas of the small intestines and females exhibited a statistically significant increase in alveolar/bronchiolar adenomas.

Environmental Fate

Soil. Hydrolyzes in soil to ethyl mercaptan, carbon dioxide and diisobutylamine (Hartley and Kidd, 1987). Butylate is probably subject to degradation of soil microorganisms. It was reported that butylate may degrade via hydrolysis of the ester linkage forming the corresponding mercaptan (ethyl mercaptan), alkylamine (diisobutylamine) and carbon dioxide. Transthiolation and oxidation of the mercaptan forms the alcohol which may further oxidize to afford a metabolic pool (Kaufman, 1967). Somasundaram and Coats (1991) reported butylate in soils is oxidized to the corresponding sulfoxide. The reported half-life in soil is approximately 1.5–10 weeks (Worthing and Hance, 1991). The reported half-life of butylate in a loam soil at 21–27°C was 3 weeks (Humburg et al., 1989). Residual activity in soil is limited to approximately 4 months (Hartley and Kidd, 1987).
Groundwater. According to the U.S. EPA (1986) butylate has a high potential to leach to groundwater.
Plant. In plants, butylate is metabolized to carbon dioxide, diisobutylamine, fatty acids, conjugates of amines and other compounds (Hartley and Kidd, 1987; Humburg et al., 1989).

1,2,4-Tributylphosphorotrithioate Preparation Products And Raw materials

Raw materials

Preparation Products

1,2,4-Tributylphosphorotrithioate Suppliers

Global( 58)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29824	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
PT CHEM GROUP LIMITED		China	35426	58	Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	China	23048	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
R&D Scientific Inc.	+1-2266000236	Canada	1479	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
LEAPCHEM CO., LTD.	58
R&D Scientific Inc.	58

78-48-8(1,2,4-Tributylphosphorotrithioate)Related Search:

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MERPHOS S,S,S-TRILAURYLTHIONOPHOSPHATE 1,2,4-Tributylphosphorotrithioate S.S.S-TRIBUTYLPHOSPHOROTRITHIOATE SOLUTION 100UG/ML IN ACETONITRILE 1ML S,S,S-TRIETHYLPHOSPHOROTRITHIOATE

S,S,S-trimethyl phosphorotrithioate

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1-[bis(butylthio)phosphorylthio]butane 1-bis(butylsulfanyl)phosphorylsulfanylbutane S,S,S-Tributyl phosphorotrithioate 250mg [78-48-8] Tribufos (DEF) C1orf107 Digestive organ expansion factor homolog Butiphos E-Z OFF D CHEMAGRO B-1776 DEF DEGREEN DEF powder DEF(R) Tribufos Solution, 100ppm S,S,S-TRIBUTYLPHOSPHOROTRITHIOATE TRIBUFOS B-1,776 Butifos Phosphorotrithioicacid,S,S,S-tributylester s,s,s-tributyl S,S,S-Tributyl trithiophosphate S,S,S-Tributyltrithiofosfat s,s,s-tributyltrithiophosphate TBTP 1,2,4-tributylphosphorotrithioate Butyl phosphorotrithioate Butyl Phosphorotrithioate ((BuS)3PO) butylphosphorotrithioate butylphosphorotrithioate((bus)3po) Chemagro 1,776 chemagro1,776 DEF Defoliant defdefoliant Fosfall fossfall Ortho phosphate defoliant orthophosphatedefoliant Phosphorotrithioic acid, S,S,S-tributyl ester FOS-FALL ''A'' Tribuphos Tributylphosphorotrithioate S,S,S-TRIBUTYLPHOSPHOROTRITHIOATE, 1GM, NEAT For Fall A Trithiophosphoric acid S,S,S-tributyl DEF 6 MERPHOSOXIDE S,S,S-TRI-N-BUTYLPHOSPHOROTRITHIOATE Defoliation phosphate TribufosSolution,1,000mg/L,1mL TribufosSolution,100mg/L,1mL TribufosSolution,2,000mg/L,1mL Tribufos Solution in Methanol, 100μg/mL ANTI-DEF (N-TERM) antibody produced in rabbit 1-(2-chloroethyl)-3-(2,2,3,3,4,4,5,5,6,6-decafluorocyclohexyl)-1-nitrosourea Tribufos Solution in Methanol Fruquintinib Impurity 12 78-48-8 C12H27OPS3