Clindamycin phosphate
- CAS No.
- 24729-96-2
- Chemical Name:
- Clindamycin phosphate
- Synonyms
- Clindets;Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2-pyrrolidinyl]carbonyl]amino]-2-O-phosphono-1-thio-L-threo-α-D-galacto-octopyranoside;Methyl 7-chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate);Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-(dihydrogenphosphate);methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside 2-(dihydrogen phosphate);Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2α-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside 2-dihydrogen phosphate;u28508;U-28508E;dalacinp;Dalacin T
- CBNumber:
- CB8175076
- Molecular Formula:
- C18H34ClN2O8PS
- Molecular Weight:
- 504.96
- MOL File:
- 24729-96-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 12:20:35
| Melting point | 114 °C |
|---|---|
| Boiling point | 159°C |
| Density | 1.41±0.1 g/cm3(Predicted) |
| refractive index | 122 ° (C=1, H2O) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble224mg/mL at 25°C |
| form | solid |
| pka | pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain) |
| color | White |
| Water Solubility | Freely soluble in water |
| Merck | 14,2356 |
| Stability | Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins. |
| InChIKey | UFUVLHLTWXBHGZ-YFBDLMQENA-N |
| SMILES | [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1)O)([C@@H](Cl)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O |&1:0,2,4,5,7,13,18,23,26,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319-H362 | |||||||||
| Precautionary statements | P260-P263-P280-P301+P312-P302+P352-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GF2625000 | |||||||||
| HS Code | 29419000 | |||||||||
| NFPA 704 |
|
Clindamycin phosphate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1021 | Clindamycin Phosphate Pharmaceutical Secondary Standard; Certified Reference Material | 24729-96-2 | 1G | ₹9590.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6427 | Clindamycin 2-phosphate aminoglycoside antibiotic | 24729-96-2 | 50MG | ₹12470.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C6427 | Clindamycin 2-phosphate aminoglycoside antibiotic | 24729-96-2 | 100MG | ₹21498.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2257 | Clindamycin Phosphate | 24729-96-2 | 5G | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2257 | Clindamycin Phosphate | 24729-96-2 | 25G | ₹14400 | 2022-05-26 | Buy |
Clindamycin phosphate Chemical Properties,Uses,Production
Chemical Properties
solid or colorless solution with characteristic alcohol odor.
Preparation
Preparation of Clindamycin Phosphate: a solution of 808 mg of the phosphorylated ester in 6 ml of pyridine and 16 ml of acetic acid is stirred at ambient temperature while s5 mg of zinc is rapidly added. The mixture is filtered after one hour and evapo rated to a residue which is heated with stirring at 50°C. for 2 hours with a solvent mixture of 2 ml of acetic acid, and 4 ml of 0.5N sulfuric acid. The mixture is cooled and filtered followed by evaporation of the filtrate in vacuo to a residue, which is chromatographed on a suitable ion-exchange resin, in the acid form, and eluted with 2% ammonium hydroxide. The desired product is obtained as ammonium salt by evaporation of the product fractions. (dec. 212°C)
General Description
Clindamycin phosphate (Cleocin Phosphate) is the 2-phosphateester of clindamycin. It exists as a zwitterionic structurethat is very soluble in water. It is intended for parenteral(intravenous or intramuscular) administration for the treatmentof serious infections and instances when oral administrationis not feasible. Solutions of clindamycin phosphateare stable at room temperature for 16 days and for up to 32days when refrigerated.
Contact allergens
This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.
Pharmacology
Clindamycin phosphate is available in 1% concentration in a hydroalcoholic vehicle (30 or 60 mL) as a gel or lotion. Although the drug has not been detected in the blood after topical use, its detection in the urine suggests that 4% to 5% of topically applied clindamycin is absorbed.
Clindamycin phosphate Preparation Products And Raw materials
Global( 585)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Hindustan Chemicals & Pharmaceuticals | 08048966818 | Mumbai, India | 34 | 58 | Inquiry |
| Unique Pharmaceutical Labs. (a. Div. Of J. B.... | 08048372654Ext 822 | Gujarat, India | 6 | 58 | Inquiry |
| Shaivya Pharmachem. | 08048371708Ext 729 | Gujarat, India | 56 | 58 | Inquiry |
| Aspire Healthchare And Chemicals | 08069013893Ext 558 | Gujarat, India | 18 | 58 | Inquiry |
| CAD Pharma Inc | 08048372459Ext 215 | Karnataka, India | 12 | 58 | Inquiry |
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24729-96-2(Clindamycin phosphate)Related Search:
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(2s-trans)-
2-(dihydrogenphosphate
U-28508E
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CLINDAMYCINPHOSPHATE,CRYSTAL,USP
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L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α- (8CI)
L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-
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methyl (2S-trans)-7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside, 2-(dihydrogen phosphate)
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[(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate