Lincomycin hydrochloride
- CAS No.
- 859-18-7
- Chemical Name:
- Lincomycin hydrochloride
- Synonyms
- LINCOMYCIN HCL;Lincomycin hydrochloride monohydrate;Lincorex;Lintamycin;METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;Lizpion;U-10149A;Lincogap;Lincocin;Luniamycin
- CBNumber:
- CB8141837
- Molecular Formula:
- C18H35ClN2O6S
- Molecular Weight:
- 443
- MOL File:
- 859-18-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/12 21:57:18
| Melting point | 156-158C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | solid |
| color | white to white with yellow cast |
| Water Solubility | Soluble in water. |
| BRN | 4171650 |
| Stability | Hygroscopic |
| InChIKey | POUMFISTNHIPTI-BOMBIWCESA-N |
| SMILES | [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r| |
| EPA Substance Registry System | D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | RH6315000 |
| F | 10 |
| HS Code | 29419000 |
Lincomycin hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L6004 | Lincomycin hydrochloride ≥90% (TLC) | 859-18-7 | 1000000UNITS | ₹6928 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L6004 | Lincomycin hydrochloride ≥90% (TLC) | 859-18-7 | 5000000UNITS | ₹26413 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L6004 | Lincomycin hydrochloride ≥90% (TLC) | 859-18-7 | 25000000UNITS | ₹66974.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L2774 | Lincomycin hydrochloride BioReagent, suitable for cell culture | 859-18-7 | 1000000UNITS | ₹6928 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L2774 | Lincomycin hydrochloride BioReagent, suitable for cell culture | 859-18-7 | 5000000UNITS | ₹24399.55 | 2022-06-14 | Buy |
Lincomycin hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
General Description
Chemical structure: macrolide
Clinical Use
Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.
Lincomycin hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| Opulent Pharma | 08068441147Ext 981 | Gujarat, India | 810 | 58 | Inquiry |
| Indo Pharma | 91-9869660535 | Maharashtra, India | 99 | 58 | Inquiry |
| Medi Pharma Drug House | 91-22-61904500 (100 Lines) | Maharashtra, India | 81 | 58 | Inquiry |
| Rumit International (part of Rumit Group of Companies) | 91-22-61418100 | Maharashtra, India | 75 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| Vapoor Chemicals | 91-22-26590197 | Maharashtra, India | 71 | 58 | Inquiry |
| Dilipkumar & Co | 91-22-23540021 | Maharashtra, India | 49 | 58 | Inquiry |
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