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HOE 140

CAS No.: 130308-48-4

Chemical Name:: HOE 140

Synonyms: S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP

CBNumber:: CB1318492

Molecular Formula:: C59H89N19O13S

Molecular Weight:: 1304.52

MOL File:: 130308-48-4.mol

MSDS File:: SDS

Modify Date:: 2024/6/5 17:10:12

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HOE 140 Properties

Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
form	powder
pka	3.60±0.21(Predicted)
color	white
Water Solubility	Soluble to 1 mg/ml in water
Sequence	H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey	QASONHYHOCRAHL-DOMVFXHKSA-N
CAS DataBase Reference	130308-48-4

SAFETY

Risk and Safety Statements

WGK Germany	3

HOE 140 Chemical Properties,Uses,Production

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).

Definition

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.

brand name

Metastat (CollaGenex).

References

[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.

HOE 140 Preparation Products And Raw materials

Raw materials

Preparation Products

HOE 140 Suppliers

Global( 132)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
Shanghai Aosiris new Material Technology Co., LTD	86-15139564871 +8615139564871	China	264	58	Inquiry
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	China	973	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Otto Chemie Pvt. Ltd.	58
Pharma Affiliates	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shanghai Aosiris new Material Technology Co., LTD	58
hebei hongtan Biotechnology Co., Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60

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RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH Icatibant D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Thi-L-Ser-D-Tic-L-Oic-L-Arg-OH H0E-140 D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-3-(2-Thienyl)-L-Ala-L-Ser-D-Tic-[(3aS,7aS)-L-Oic-]-OH Des-Arg9-D-Arg[Hyp3,Thi5,D-Tic7,Oic8]bradykinin S-0765 138614-30-9 (Acetate) Icatibant [inn] L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl- HOE I40 HOE 140 HOE 140 2ACOH 4H2O D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG 2ACOH 4H2O D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ D-ARGINYL-[HYP3,THI5,D-TIC7,OIC8]-BRADYKININ 2ACOH 4H2O D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA, 3BETA, 7ABETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL D-ARGINYL-L-ARGINLYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2ALPHA,3BETA,7A-BETA)-OCTAHYDRO-1H-INDOLE-2-CARBONYL-L-ARGININE [DES-ARG10] HOE 140 D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic D-Arg-L-Arg-L-prolyl-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carboxylic acid HOE 140 USP/EP/BP L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl- Nw-(((S)-2-(2-((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-N2-((3aS,7aS)-octahydro-1H-indole-2-carbonyl)-N2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-arginine JE-049) Icatibant (HOE-140 Icatibatide Acetate Etibant HOE 140 TFA ((2S,3aS,7aS)-1-((R)-2-(((S)-2-(2-((2S,4R)-1-(D-Arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanoyl)-L-seryl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)octahydro-1H-indole-2-carbonyl)-L-arginine Phytol Impurity 3 130308-48-4 C53H77N15O12S C59H90N20O12S peptide