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HOE-140

HOE-140 Structure
CAS No.
138614-30-9
Chemical Name:
HOE-140
Synonyms
CS-1399;Firazyr;HOE 140 Acetate;lcatibant Acetate;Aldeibant acetate;HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg
CBNumber:
CB5497052
Molecular Formula:
C59H89N19O13S.C2H4O2
Molecular Weight:
1364.59
MOL File:
138614-30-9.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

HOE-140 Properties

storage temp. -20°C
solubility DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
form A crystalline solid
color White to off-white

SAFETY

Risk and Safety Statements

WGK Germany  3

HOE-140 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) H157 HOE 140 ≥94% 138614-30-9 250μG ₹28653.78 2022-06-14 Buy
Product number Packaging Price Buy
H157 250μG ₹28653.78 Buy

HOE-140 Chemical Properties,Uses,Production

Description

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.

Uses

Antagonist (bradykinin).

Definition

ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

HOE-140 Preparation Products And Raw materials

Raw materials

Preparation Products

HOE-140 Suppliers

Global( 123)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Biophore India Pharmaceuticals Pvt Ltd +91-9100031592 +91-9030907714 Telangana, India 134 58 Inquiry
Mylan Laboratories Ltd +91-4023550543 +91-4030866666 Telangana, India 150 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Dorne Chemical Technology co. LTD +86-86-13583358881 +8618560316533 China 3146 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
Hebei Xinsheng New Material Technology Co., LTD. +86-16632316109 China 1090 58 Inquiry
Nantong Guangyuan Chemicl Co,Ltd +undefined17712220823 China 616 58 Inquiry
Supplier Advantage
Biophore India Pharmaceuticals Pvt Ltd 58
Mylan Laboratories Ltd 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
SynZeal Research Pvt Ltd 58
Dorne Chemical Technology co. LTD 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Hebei Xinsheng New Material Technology Co., LTD. 58
Nantong Guangyuan Chemicl Co,Ltd 58

HOE-140 Spectrum

HOE-140(138614-30-9)MS

138614-30-9(HOE-140)Related Search:

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1-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-amine N-BENZYL-1-(1-PYRROLIDINYL)-2-PROPANAMINE
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Firazyr HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg HOE 140 Acetate lcatibant Acetate HOE-140 (Icatibant) HOE140; ICATIBANT;HOE 140 CS-1399 (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propanoyl]amino]-3-hydroxy-propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140 Aldeibant acetate 138614-30-9 C59H89N19O13SxC2H4O2 C59H89N19O13S C59H90N20O12SC2H4O2n