Gonadorelin acetate
- CAS No.
- 34973-08-5
- Chemical Name:
- Gonadorelin acetate
- Synonyms
- Gonaderelin acetate;Gonadorelin Acetate 2mg;GONADORELIN(2MG);Gonadelin Acetate;GONADORELIN ACETATE;Gonadorelin acetate salt;Gonadorelin Acetate/GnRH;Gonadorelin Acetate(acetate);(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methy
- CBNumber:
- CB22130587
- Molecular Formula:
- C57H79N17O15
- Molecular Weight:
- 1242.36
- MOL File:
- 34973-08-5.mol
- Modify Date:
- 2025/3/7 18:45:43
| Melting point | >155oC (dec.) |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, Under inert atmosphere |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | NGCGMRBZPXEPOZ-NWVXUHCVNA-N |
| CAS DataBase Reference | 34973-08-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H361 |
| Precautionary statements | P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
Gonadorelin acetate Chemical Properties,Uses,Production
Description
Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Uses
Gonadorelin Acetate is used in various agricultural and biological studies. It was used to study ovulation synchronization in dairy cows.
Synthetic GnRH (gonadorelin hydrochloride [Factrel]) is marketed for diagnostic purposes to differentiate between pituitary and hypothalamic defects in patients with delayed puberty and hypogonadotropic hypogonadism. After a baseline serum LH is drawn, a single 100-mcg GnRH dose is administered subcutaneously or intravenously. An increase in serum LH of greater than 10 mIU/ml is considered a positive response. Synthetic GnRH (gonadorelin acetate [Lutrepulse]) is marketed for the treatment of infertile women who are anovulatory and have GnRH deficiency. In this protocol, a pump administers GnRH in pulses to promote a physiologic cycle. Because of the complexity of administration, this treatment modality was rarely used, and this product is no longer available in the United States.
Application
Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)
Indications
Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.
Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.
Biological Activity
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
Pharmacology
Gonadorelin is an agonist of the GnRH receptor and is used to induce the secretion of the gonadotropins follicle-stimulating hormone and luteinizing hormone from the pituitary gland and to increase sex hormone production by the gonads.
Gonadorelin has a distribution half-life of 2 to 10 minutes and a very short terminal half-life of 10 to 40 minutes. It is metabolized by hydrolysis into smaller peptide components.
Side effects
Gonadorelin side effects: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or. skin rash.
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Gonadorelin acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Angel Bio Pharma | 08069013898Ext 347 | Ahmedabad, India | 50 | 58 | Inquiry |
| Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 | China | 84 | 58 | Inquiry |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 995 | 58 | Inquiry |
| Qingdao Xinli Technology Development Co., Ltd. | +8616632313095 | China | 124 | 58 | Inquiry |
| hebei hongtan Biotechnology Co., Ltd | +852-6619 3215 +86-17731935328 | China | 970 | 58 | Inquiry |
| Shandong Huizhihan Supply Chain Co., Ltd | +86-13363081709 +86-13363000288 | China | 300 | 58 | Inquiry |
| American HealthyMorph LLC | +8613363867578 | China | 169 | 58 | Inquiry |
| Hebei Jiafan Trading Company Limited | +8615354498258 | China | 150 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | China | 8808 | 58 | Inquiry |
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