Nafarelin Acetate
- CAS No.
- 86220-42-0
- Chemical Name:
- Nafarelin Acetate
- Synonyms
- NAFARELIN ACETATE;Nafarelin impurity;NAFARELIN ACETATE HYDRATE;Nafarelin Acetate n-Hydrate;Nafarelin acetate naphthalene;Nafarelin acetate salt hydrate;Nafarelin Acetate Hydrate (1:x:x);Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate;Luteinizing hormone-releasing factor (swine), 6-(3-(2-naphthalenyl)-D-alanine)-, acetate (salt), hydrate;5-OXO-L-PROLYL-L-HISTIDYL-L-TRYPTOPHYL-L-SERYL-L-TYROSYL-3-(2-NAPHTHYL)-D-ALANYL-L-LEUCYL-L-ARGINYL-L-PROLYLGLYCINAMIDE ACETATE HYDRATE
- CBNumber:
- CB6154226
- Molecular Formula:
- C68H89N17O16
- Molecular Weight:
- 1400.54
- MOL File:
- 86220-42-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/2 10:52:22
| Melting point | >181oC (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white |
| EPA Substance Registry System | Nafarelin acetate (86220-42-0) |
Nafarelin Acetate Chemical Properties,Uses,Production
Description
Nafarelin acetate is a synthetic decapeptide agonist analog of the natural gonadotropin-releasing hormone, differing in the amino acid at position 6 where D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin greater potency and a substantially longer half-life than the endogenous hormone. Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated dosing and is indicated for the management of endometriosis. It also has orphan drug status for use in precocious puberty.
Uses
Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.
Clinical Use
Nafarelin acetate, contains D Nal(2)6 [Nal = 3-(2-naphthyl)-Ala] in place of Gly6, but the C-terminus, Gly10-NH2, is identical
with natural GnRH. Nafarelin acetate is available as a 0.2% nasal spray for the relief
of endometriosis. Estrogen, of course, is needed for the growth of endometrial tissue; thus, decreased estrogen leads to shrinkage of errant endometrial tissue. The observed side effects of nafarelin acetate are related to falling estrogen levels and include decreased libido,
amenorrhea, hot flashes, and vaginal dryness. When used consistently, nafarelin acetate will
inhibit ovulation and stop menstruation.
Nafarelin acetate also is used in children, male and female, for the treatment of central
precocious puberty. By suppressing the release of LH, the estradiol or testosterone levels fall to
prepubertal levels; early secondary sexual development is arrested, linear growth and skeletal
maturation are slowed, and in girls, menstruation stops.
Nafarelin Acetate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 11027 | 58 | Inquiry |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 999 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | China | 376 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | China | 4692 | 58 | Inquiry |
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