Leuprorelin acetate
- CAS No.
- 74381-53-6
- Chemical Name:
- Leuprorelin acetate
- Synonyms
- LEUPROLIDE;Leuprolide acetate;lupron;Leuprolide acetate (Leuprorelin acetate);6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig);tap-144;Prostap;Procrin;TPA-144;DC-2-269
- CBNumber:
- CB7174300
- Molecular Formula:
- C61H88N16O14
- Molecular Weight:
- 1269.47
- MOL File:
- 74381-53-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/10 15:15:42
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P332+P313-P362+P364 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | OH6390000 | |||||||||
| HS Code | 29371900 | |||||||||
| NFPA 704 |
|
Leuprorelin acetate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L0399 | Leuprolide acetate salt ≥98% (HPLC) | 74381-53-6 | 1MG | ₹11214.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3193 | Leuprolide Acetate pharmaceutical secondary standard, certified reference material | 74381-53-6 | 5MG | ₹61605.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L0399 | Leuprolide acetate salt ≥98% (HPLC) | 74381-53-6 | 5MG | ₹37595.23 | 2022-06-14 | Buy |
Leuprorelin acetate Chemical Properties,Uses,Production
Description
Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.
Chemical Properties
Fluffy Solid
Uses
Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
Definition
ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Pharmacology
Leuprolide, 5-oxo-L-prolyl-L-histadyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucil-L-leucil-L-arginyl-N-ethyl-L-prolinamide (30.5.9), is made synthetically.
pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
The nonapeptide leuprolide is a synthetic analog of the decapeptide, gonadotropin releasing hormone, and it exceeds the activity of the natural hormone and significantly elevates
the level of testosterone and dihydrotestosterone in men, and estrogen in women. It also
inhibits follicle-stimulating hormone and leutenizing hormone.
Leuprolide is used for prostate cancer, when orchiectomy or estrogen therapy is counterproductive to the patient. A synonym of this drug is lupron.
Side effects
Side effects: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue; breathing problems; chest pain; depression or memory disorders; pain in your legs or groin; pain at site where injected or implanted; seizures; severe headache; signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision; swelling of the feet and legs; suicidal thoughts or other mood changes; visual changes; vomiting
Drug interactions
Leuprorelin acetate can not take with mang drugs, such as chasteberry, cisapride, dronedarone, pimozide, or thioridazine. This medicine may also interact with the following medications: herbal or dietary supplements, like black cohosh or DHEA; female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections; male hormones, like testosterone; other medicines that prolong the QT interval (abnormal heart rhythm).
Leuprorelin acetate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Aligns International | 91-22-22634745 | Maharashtra, India | 137 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Congruent Pharmachem Pvt., Ltd. | 91-9987911266 | Maharashtra, India | 35 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt. Ltd | -40560491 | Mumbai, India | 23 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Zydus Takeda Healthcare Pvt. Ltd. | 91-22-68375200 | Maharashtra, India | 6 | 58 | Inquiry |
| Mesha Pharma Private Limited | 08048372569Ext 806 | Mumbai, India | 133 | 58 | Inquiry |
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