Leuprorelin acetate
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- CAS-Nr.
- 74381-53-6
- Englisch Name:
- Leuprorelin acetate
- Synonyma:
- LEUPROLIDE;Leuprolide acetate;lupron;Leuprolide acetate (Leuprorelin acetate);6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig);tap-144;Prostap;Procrin;TPA-144;DC-2-269
- CBNumber:
- CB7174300
- Summenformel:
- C61H88N16O14
- Molgewicht:
- 1269.47
- MOL-Datei:
- 74381-53-6.mol
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Leuprorelin acetate Eigenschaften
- Schmelzpunkt:
- 150-155°C
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Merck
- 14,5457
- InChIKey
- RGLRXNKKBLIBQS-XNHQSDQCSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
22-24/25 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
OH6390000 |
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| HS Code |
29371900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Leuprorelin acetate Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical
castration in the treatment of advanced prostate cancer. It has also been
investigated for the treatment of advanced breast cancer.
Chemische Eigenschaften
Fluffy Solid
Verwenden
Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
Definition
ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t
eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Pharmakologie
Leuprolide, 5-oxo-L-prolyl-L-histadyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucil-L-leucil-L-arginyl-N-ethyl-L-prolinamide (30.5.9), is made synthetically.
pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
The nonapeptide leuprolide is a synthetic analog of the decapeptide, gonadotropin releasing hormone, and it exceeds the activity of the natural hormone and significantly elevates
the level of testosterone and dihydrotestosterone in men, and estrogen in women. It also
inhibits follicle-stimulating hormone and leutenizing hormone.
Leuprolide is used for prostate cancer, when orchiectomy or estrogen therapy is counterproductive to the patient. A synonym of this drug is lupron.
Arzneimittelwechselwirkung
Leuprorelin acetate can not take with mang drugs, such as chasteberry, cisapride, dronedarone, pimozide, or thioridazine. This medicine may also interact with the following medications: herbal or dietary supplements, like black cohosh or DHEA; female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections; male hormones, like testosterone; other medicines that prolong the QT interval (abnormal heart rhythm).
Leuprorelin acetate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Leuprorelin acetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 379)Lieferanten
74381-53-6()Verwandte Suche:
- leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid
- tap-144
- Abbott 43818
- Procren Depot
- Procrin
- Prostap
- M.W. 1209.40 C59H84N16O12
- DC-2-269
- TPA-144
- [Des-Gly10,Dleu6, ProNHEt9] LH-RH, AcetateLeuprolide, Acetate
- Leuprorelin acetate
- Leuprorelin Acetate (See L1881)
- (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
Leuprorelin, Leuprolide
- Leuprolide Acetate (200 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
- 6-D-Leucine-9-(N-ethyl-L-prolinaMide)-
- Leuprorelin, Leuprolide
- Leuprorelin, des-Gly10-[D-Leu6]-LH-RH ethylamide
- Leuprorelin acetate, Ph. Eur.
- Monoacetate (salt)
- tap-144-sr
- DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE
- [DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN)
- (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
- (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
- [DES-GLY10, D-LEU6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN
- [DES-GLY10, DLEU6, PRO9]-LH-RH, ETHYL AMIDE
- [DES-GLY10, DLEU6, PRO9]-LUTEINIZING HORMONE-RELEASING HORMONE, ETHYL AMIDE
- [DES-GLY10, DLEU 6, PRONHET9]
- (DES-GLY10,D-LEU6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
- (DES-GLY10,D-LEU6,PRO-NHET9)-LHRH
- GLP-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- LH-RH LEUPROLIDE
- LEUPROLIDE (HUMAN)
- 5-OXOPRO-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5
- PYR-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- PYROGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO NHCH2CH3
- PGLU-HIS-TRP-SER-TYR-P-LEU-LEU-ARG-PRO-NHET
- PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- Leuprolide 53714-56-0 / Acetate
- des-gly10-[d-leu6]-lh-rh ethylamide
- leuprolide acetate salt
- LEUPROPELINACETATE
- Leuprorelin acetate, 98%, an agonist at pituitary GnRH receptors
- Leuprorelin Acetate RS
- Leuproprelin acetate
- (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-15,18-diisobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamideacetate
- Leuprorelin?Acetate impurity
- Leuprorelin acetate USP/EP/BP
- Leuprolide Acetate (53714-56-0 free base)
- Leuprorelin AcetateQ: What is
Leuprorelin Acetate Q: What is the CAS Number of
Leuprorelin Acetate Q: What is the storage condition of
Leuprorelin Acetate Q: What are the applications of
Leuprorelin Acetate
- Leuprorelin D10 Acetate
- Leuprolide Acetate(acetate)
- Leuprolide Acetate (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) (1358503)
- lupron
- 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig)
- Leuprolide acetate
- LEUPROLIDE
- Leuprolide acetate (Leuprorelin acetate)
