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Cetrorelix acetate

CAS No.: 120287-85-6

Chemical Name:: Cetrorelix acetate

Synonyms: CETRORELIX;Cetrorelixum;Unii-oon1hfz4ba;CETRORELIX ACID;Cetrorelix acetate;Cetrorelixum [inn-latin];CETRIZINEDIHYDROCHLORIDE;Cetrorelix?Acetate impurity;Cetrorelix acetate USP/EP/BP;Cetrorelix(Cetrorelix acetate)

CBNumber:: CB0316370

Molecular Formula:: C70H92ClN17O14

Molecular Weight:: 1431.04

MOL File:: 120287-85-6.mol

MSDS File:: SDS

Modify Date:: 2024/5/29 17:03:55

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Cetrorelix acetate Properties

Melting point	>259°C (dec.)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly)
form	Solid
pka	9.82±0.15(Predicted)
color	White to Off-White
InChIKey	SBNPWPIBESPSIF-MHWMIDJBSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360

Cetrorelix acetate Chemical Properties,Uses,Production

Description

Cetrorelix was launched in Germany for the treatment of female infertility. It is a decapeptidic analog of luteinizing hormone-releasing hormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3, 6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelix is an extremely potent and long acting gonadotrophin releasing hormone (GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretion immediately after administration. Moreover, it has a low histamine-releasing potency. Cetrorelix will be the first LH-RH antagonist approved worldwide. In several Phase III clinical trials, female patients receiving Cetrorelix had a successful controlled ovulation thus avoiding a premature LH-surge. Cetrorelix could be a first-choice in-vitro fertilization (IVF) treatment without the complications of current controlled ovarian hyperstimulation protocols. Cetrorelix is currently under clinical investigation for the treatment of diverse sex hormone dependent disorders such as benign prostate hypertrophy, breast, ovarian or prostate cancers and diverse gynaecological disorders.

Definition

ChEBI: A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-t rosyl, N5-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.

Cetrorelix acetate Preparation Products And Raw materials

Raw materials

Boc-Arg(Tos)-OH BOC-L-Proline BOC-L-Leucine

Preparation Products

Cetrorelix acetate Suppliers

Global( 244)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
EAGLE CHEMICAL WORKS	+91-22263303652226330365 +91-2226330365	Maharashtra, India	61	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Biophore India Pharmaceuticals Pvt Ltd	+91-9100031592 +91-9030907714	Telangana, India	134	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49999	58	Inquiry

Supplier	Advantage
EAGLE CHEMICAL WORKS	58
Ralington Pharma	58
Biophore India Pharmaceuticals Pvt Ltd	58
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
Manus Aktteva	34
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
AFINE CHEMICALS LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58

Cetrorelix acetate Spectrum

Cetrorelix acetate(120287-85-6)MS

120287-85-6(Cetrorelix acetate)Related Search:

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Cetrorelix acetate CETRORELIX ACID CETRIZINEDIHYDROCHLORIDE N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 Cetrorelixum Cetrorelixum [inn-latin] Unii-oon1hfz4ba Ac-D-2-Nal-4-chloro-D-Phe-β-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 acetate salt D-AlaninaMide,N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aMinocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl- Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH Cetrorelix?Acetate impurity Cetrorelix acetate USP/EP/BP Cetrorelix(Cetrorelix acetate) Ac-D2Nal-D4Cpa-D3Pal-DSer-Tyr-DCit-Leu-Arg-Pro-DAla-NH2 CETRORELIX 120287-85-6 20287-85-6 C70H92ClN17O14 C70H92CIN17O14C2H4O2 Peptide GYL