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Atosiban

CAS No.: 90779-69-4

Chemical Name:: Atosiban

Synonyms: Antocin;rwj22164;Atosiban;RW-22164;ORF22164;ORF 22164;ORF-22164;14-Deoxy-11;atosiban price;Human Atosiban

CBNumber:: CB7497854

Molecular Formula:: C43H67N11O12S2

Molecular Weight:: 994.19

MOL File:: 90779-69-4.mol

MSDS File:: SDS

Modify Date:: 2024/6/17 17:42:23

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Atosiban Properties

Melting point	>165oC (dec.)
Boiling point	1469.0±65.0 °C(Predicted)
Density	1.254±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	H₂O: ≤100 mg/mL
form	solid
pka	12.81±0.70(Predicted)
color	White to Off-White
Water Solubility	Soluble to 50 mg/ml in water
CAS DataBase Reference	90779-69-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P261-P280
WGK Germany	3
RTECS	RS7590000
HS Code	2934999090

Atosiban price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A3480	Atosiban ≥98% (HPLC)	90779-69-4	10MG	₹27279	2022-06-14	Buy

Product number	Packaging	Price	Buy
A3480	10MG	₹27279	Buy

Atosiban Chemical Properties,Uses,Production

Description

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V_1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

Uses

Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

Indications

Atosiban is an analogue of oxytocin that is modified at positions 1, 2, 4, and 8. It is a competitive inhibitor of oxytocin binding. Early studies have demonstrated that this drug does decrease and stop uterine contractions. Atosiban is not available for use in the United States.

Anticancer Research

The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).

Atosiban Preparation Products And Raw materials

Raw materials

Dicyclohexylcarbodiimide BOC-ORN-OH D-Tyrosine, O-ethyl- (9CI) N,N-Diisopropylethylamine BOC-L-Asparagine

1-Hydroxybenzotriazole 3-Mercaptopropionic acid Boc-L-Threonine BOC-CYS-OH

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Preparation Products

Atosiban Suppliers

Global( 347)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	China	305	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	11027	58	Inquiry
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	China	616	58	Inquiry
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	China	274	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21676	55	Inquiry

Supplier	Advantage
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shanghai Getian Industrial Co., LTD	58
Henan Tianfu Chemical Co.,Ltd.	55

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1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l rwj22164 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin [Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2 (2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin Atosiban Human Atosiban 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile, 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin Atosiban,1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin, 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile Atosiban, RWJ 22164 Oxytropis Falcata AtosibanAcetate(Tractocile) 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond) Atosiban impurity 1 Atosiban, >=98% (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, Atosiban 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide ATOSIBAN ACETATE Glycinamide, O-ethyl-N-(3-mercapto-1-oxopropyl)-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithyl-, cyclic (1→5)-disulfide Atosiban impurity Atosiban Impurity 41 Atosiban USP/EP/BP Atosiban DISCONTINUED PLEASE SEE A791890 Atosiban acetate salt (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)p AtosibanQ: What is Atosiban Q: What is the CAS Number of Atosiban Q: What is the storage condition of Atosiban Q: What are the applications of Atosiban Atosiban Acetate(net) 12-didehydroandrographolide 14-Deoxy-11 RW-22164 RW-22164;RWJ-22164 Atosiban Impurtiy atosiban price (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt Antocin (Deamino-Cys?,D-Tyr(Et)?,Thr?,Orn?)-Oxytocin acetate salt ORF 22164 ORF22164 ORF-22164 90779-69-4 C45H71N11O14S2 C43H67N11O12S2 hormones Peptide 90779-69-4 API