Sineptina
- CAS No.
- 1392-21-8
- Chemical Name:
- Sineptina
- Synonyms
- KITASAMYCIN;LEUCOMYCIN HYDRATE;KITASAMYCIN BASE;c637;Ayermycin;Sineptina;Syneptine;ayermicina;guitamycin;FORMACIDINE
- CBNumber:
- CB1338872
- Molecular Formula:
- C35H59NO13
- Molecular Weight:
- 701.84186
- MOL File:
- 1392-21-8.mol
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 128-145 °C |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | ethanol: 50 mg/mL, clear to slightly hazy, light-yellow |
| form | Solid |
| color | White to Off-White |
| Merck | 14,5453 |
| CAS DataBase Reference | 1392-21-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Safety Statements | 24/25 |
| WGK Germany | 1 |
| RTECS | WG9400000 |
| F | 10 |
| HS Code | 29419090 |
| Toxicity | mouse,LD50,intraperitoneal,1758mg/kg (1758mg/kg),Drugs in Japan Vol. -, Pg. 354, 1995. |
Sineptina Chemical Properties,Uses,Production
Description
Kitasamycin, formerly called leucomycin, was found in the culture broth of Streptoverticillium kitasatoensis by Hata et al. of the Kitasato Institute, Japan, in 1953. This was the first macrolide antibiotic with a 16-membered lactone constituent. Kitasamycin is a complex of eight leucomycin A components and is used in its base and ester forms to treat gram-positive bacterial and gram-negative coccal infections, as well as infections of Mycoplasma, Spirochaeta, and Treponema by injection or by oral topical administration.
Uses
Sineptina is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most abundant analogues.Sineptina is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma.
Pharmaceutical Applications
A naturally occurring product of Streptomyces kitasatoensis, available in Japan for parenteral and oral use, and as acetylkitasamycin for topical application. Elsewhere it is chiefly used in veterinary medicine.
Sineptina Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Meteoric Biopharmaceuticals Private Limited | 08046066618 | Ahmedabad, India | 23 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| AVIK PHARMACEUTICAL LIMITED | +91-22-67685000 | New Delhi, India | 54 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5831 | 58 | Inquiry |
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