ROKITAMYCIN
- CAS No.
- 74014-51-0
- Chemical Name:
- ROKITAMYCIN
- Synonyms
- M-19-Q;TMS 19Q;Rokital;Rikamycin;Ricamycin;ROKITAMYCIN;T'urimyein H4;ROKITAMYCIN USP/EP/BP;3''-Propionylleucomycin A5;Leucomycin V, 4B-butanoate 3B-propanoate
- CBNumber:
- CB1388574
- Molecular Formula:
- C42H69NO15
- Molecular Weight:
- 827.99
- MOL File:
- 74014-51-0.mol
- Modify Date:
- 2023/5/4 17:34:41
| Melting point | 116° |
|---|---|
| alpha | D20 -71° (c = 1.0 in chloroform) |
| Boiling point | 879.3±65.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 13.06±0.70(Predicted) |
| CAS DataBase Reference | 74014-51-0 |
ROKITAMYCIN Chemical Properties,Uses,Production
Description
Rokitamycin is a semisynthetic macrolide antibiotic, closely related to miokamycin(2) both in structure and antimicrobial spectrum.
Pharmaceutical Applications
3″-Propionyl leucomycin A5. A semisynthetic macrolide. Unstable in acid media.
The antibacterial spectrum is identical to that of erythromycin, but it is less active against Gram-positive cocci. It is poorly active against H. influenzae (MIC50 8 mg/L) and Mor. catarrhalis (MIC50 4 mg/L). It displays good activity against Campylobacter spp. (MIC50 0.1 mg/L), L. pneumophila (MIC50 0.1 mg/L) and M. pneumoniae (MIC50 0.003 mg/L). It is active against anaerobes, including some Bacteroides spp. (MIC50 <0.05 mg/L).
After a single oral dose of 600 mg, the peak plasma concentration was 1.9 mg/L after 0.6 h. Oral doses of 5, 10 and 15 mg/kg of a syrup formulation given to children achieved plasma concentrations of 0.26, 0.55 and 0.79 mg/L, respectively, after about 40 min. The half-life is around 2 h.
It is mainly eliminated in the bile; only about 2% appears in the urine. Its major metabolites are leucomycin A7, 10″-OH-rokitamycin (which show some antibacterial activity) and leucomycin V. In healthy adult volunteers, the proportions of rokitamycin and its metabolites in serum 30 min after a single oral dose of 1200 mg were 18% (leucomycin A7), 33% (10″-OH-rokitamycin) and 9% (leucomycin V). The pharmacokinetic behavior is not altered in patients with liver cirrhosis. It is available in Italy and Japan.
ROKITAMYCIN Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9355 | 55 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-15319487004 | China | 2132 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8331 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9976 | 58 | Inquiry |
| BOSCHE SCIENTIFIC, LLC | 732 565 9988 | United States | 6486 | 55 | Inquiry |
| AK Scientific, Inc. | 650 494 8666 | United States | 6357 | 65 | Inquiry |
| kemikalieimport | + 45 - 2034 3359 | Europe | 6699 | 47 | Inquiry |
| ecochem international chemical broker | +45 45 42 34 36 | Europe | 6385 | 66 | Inquiry |
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