ROKITAMYCIN
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ROKITAMYCIN 속성
- 녹는점
- 116°
- 알파
- D20 -71° (c = 1.0 in chloroform)
- 끓는 점
- 879.3±65.0 °C(Predicted)
- 밀도
- 1.21±0.1 g/cm3(Predicted)
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 산도 계수 (pKa)
- 13.06±0.70(Predicted)
- CAS 데이터베이스
- 74014-51-0
안전
ROKITAMYCIN C화학적 특성, 용도, 생산
개요
Rokitamycin is a semisynthetic macrolide antibiotic, closely related to miokamycin(2) both in structure and antimicrobial spectrum.Pharmaceutical Applications
3″-Propionyl leucomycin A5. A semisynthetic macrolide. Unstable in acid media.The antibacterial spectrum is identical to that of erythromycin, but it is less active against Gram-positive cocci. It is poorly active against H. influenzae (MIC50 8 mg/L) and Mor. catarrhalis (MIC50 4 mg/L). It displays good activity against Campylobacter spp. (MIC50 0.1 mg/L), L. pneumophila (MIC50 0.1 mg/L) and M. pneumoniae (MIC50 0.003 mg/L). It is active against anaerobes, including some Bacteroides spp. (MIC50 <0.05 mg/L).
After a single oral dose of 600 mg, the peak plasma concentration was 1.9 mg/L after 0.6 h. Oral doses of 5, 10 and 15 mg/kg of a syrup formulation given to children achieved plasma concentrations of 0.26, 0.55 and 0.79 mg/L, respectively, after about 40 min. The half-life is around 2 h.
It is mainly eliminated in the bile; only about 2% appears in the urine. Its major metabolites are leucomycin A7, 10″-OH-rokitamycin (which show some antibacterial activity) and leucomycin V. In healthy adult volunteers, the proportions of rokitamycin and its metabolites in serum 30 min after a single oral dose of 1200 mg were 18% (leucomycin A7), 33% (10″-OH-rokitamycin) and 9% (leucomycin V). The pharmacokinetic behavior is not altered in patients with liver cirrhosis. It is available in Italy and Japan.
ROKITAMYCIN 준비 용품 및 원자재
원자재
준비 용품
ROKITAMYCIN 공급 업체
글로벌( 22)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 2132 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9030 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 |
amber@biochempartner.com | China | 3063 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 |
1027@dideu.com | China | 9974 | 58 |