LAPACHOL
- CAS No.
- 84-79-7
- Chemical Name:
- LAPACHOL
- Synonyms
- Tecomin;CI 75490;LAPACHOL;NSC 11905;nsc-11905;taiguwood;Taigu Wood;Greenharten;Greenhartin;Groenhartin
- CBNumber:
- CB1339480
- Molecular Formula:
- C15H14O3
- Molecular Weight:
- 242.27
- MOL File:
- 84-79-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:01
| Melting point | 141-143 °C(lit.) |
|---|---|
| Boiling point | 325.09°C (rough estimate) |
| Density | 1.2077 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble10mg/mL, clear, light yellow to yellow |
| pka | 4.81±0.10(Predicted) |
| Colour Index | 75490 |
| form | Solid |
| color | Yellow to Dark Yellow |
| Merck | 13,5382 |
| InChIKey | CIEYTVIYYGTCCI-UHFFFAOYSA-N |
| LogP | 2.516 (est) |
| CAS DataBase Reference | 84-79-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL8750000 | |||||||||
| Toxicity | LD50 in male, female BALB/c mice (g/kg): 0.487; 0.792 orally (Morrison) | |||||||||
| NFPA 704 |
|
LAPACHOL Chemical Properties,Uses,Production
Description
Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis).
Occurrence
Lapacol (CI Natural Yellow 16; CI 75490) (lapachic acid, taiguie acid, tecomin) is a yellow pigment occurring in the wood of trees of the genus Tecoma, native to the West Indies and tropical South America. The shavings of the wood, treated with lime water, give an extract that dyes cotton yellow.
Uses
It was used in the synthesis of the lapachol metal complexes.
General Description
Lapachol is natural naphthoquinone compound derived from Bignoniaceae (Tabebuia sp.).
Contact allergens
Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis L., Verbenaceae family), a wood largely used for various indoor and outdoor applications (doors, windows, etc.) because of its strong durability. It has similar reactivity to deoxylapachol. Seealso Chap. 46
Purification Methods
Crystallise Lapachol from pet ether/EtOH, EtOH or Et2O. [Beilstein 8 H 326, 8 I 644, 8 II 365, 8 III 2720.]
LAPACHOL Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
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| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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