Oleyl alcohol
- CAS No.
- 143-28-2
- Chemical Name:
- Oleyl alcohol
- Synonyms
- Satol;oleyl;9-OCTADECEN-1-OL;OLEIC ALCOHOL;(Z)-9-Octadecen-1-ol;(Z)-Octadec-9-en-1-ol;Olely Alcohol;Olive alcohol;9-Octadecen-1-ol,(Z)-;9-Octadecen-1-ol, (Z)-
- CBNumber:
- CB1353439
- Molecular Formula:
- C18H36O
- Molecular Weight:
- 268.48
- MOL File:
- 143-28-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/24 22:20:23
| Melting point | 0-5.0 °C (lit.) |
|---|---|
| Boiling point | 207 °C/13 mmHg (lit.) |
| Density | 0.849 g/mL at 25 °C (lit.) |
| vapor pressure | 10.64 hPa (195 °C) |
| FEMA | 4363 | CIS-9-OCTADECENOL |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | -20°C |
| solubility | Soluble in ethanol (95%), and ether; practically insoluble in water. |
| form | Viscous Liquid |
| pka | 15.20±0.10(Predicted) |
| color | Clear almost colorless to yellow |
| Odor | fatty animal |
| Odor Type | fatty |
| Water Solubility | Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water. |
| Merck | 14,6831 |
| JECFA Number | 1637 |
| BRN | 1723962 |
| Stability | Stable. Combustible. Incompatible with strong acids, strong oxidizing agents. |
| LogP | 7.07 at 25℃ |
| CAS DataBase Reference | 143-28-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Oleyl Alcohol(143-28-2) |
| EPA Substance Registry System | 9-Octadecen-1-ol, (9Z)- (143-28-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H320 | |||||||||
| Precautionary statements | P280g-P302+P352a-P321-P332+P313-P362+P364-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | RG4120000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29052990 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Oleyl alcohol price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2637 | Oleyl Alcohol certified reference material, pharmaceutical secondary standard | 143-28-2 | 100MG | ₹9017.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O8880 | Oleyl alcohol ≥99% (GC) | 143-28-2 | 1G | ₹15739.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O8880 | Oleyl alcohol ≥99% (GC) | 143-28-2 | 5G | ₹47012.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20923 | cis-9-Octadecen-1-ol for synthesis | 143-28-2 | 100ML | ₹3510 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20923 | cis-9-Octadecen-1-ol for synthesis | 143-28-2 | 1L | ₹4360 | 2022-06-14 | Buy |
Oleyl alcohol Chemical Properties,Uses,Production
Chemical Properties
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.
Uses
oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.
Production Methods
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault–Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.
Definition
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).
General Description
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.
Pharmaceutical Applications
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and has been used in transdermal delivery formulations.It has
been utilized in the development of biodegradable injectable
thermoplastic oligomers,and in aerosol formulations of insulin
and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may
exhibit antitumor properties via transmembrane permeation.
Safety Profile
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.
Safety
Oleyl alcohol is mainly used in topical pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritant material at
the levels employed as an excipient. However, contact dermatitis
due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in
animals with products containing 8% oleyl alcohol indicate a very
low toxicity. Formulations containing 8% or 20% oleyl alcohol
administered by gastric intubation, at doses up to 10 g/kg bodyweight,
caused no deaths and no toxic effects in rats.
storage
The bulk material should be stored in a well-closed container in a cool, dry, place.
Purification Methods
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical emulsions and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Oleyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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|---|---|---|---|---|---|
| Esteem Industries Pvt. Ltd. | +91-8326613321 +91-8669968881 | Mumbai, India | 85 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Rajasthan Wool Agencies | 08045849954Ext 236 | Punjab, India | 1 | 58 | Inquiry |
| Acme Synthetic Chemicals | 08046060410 | Mumbai, India | 51 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Esteem Industries Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Central Drug House(P) Ltd. | 58 |
| Rajasthan Wool Agencies | 58 |
| Acme Synthetic Chemicals | 58 |
| Triveni chemicals | 58 |
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