DEOXYNIVALENOL
- CAS No.
- 51481-10-8
- Chemical Name:
- DEOXYNIVALENOL
- Synonyms
- DON;VOMITOXIN;Deoxynivalenol,3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin;rdtoxin;3-epi-DON;Vomintoxin;NSC 269144;DON solution;Deoxynivaleno;DEOXYNIVALENOL
- CBNumber:
- CB0391546
- Molecular Formula:
- C15H20O6
- Molecular Weight:
- 296.32
- MOL File:
- 51481-10-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 151-153 C |
|---|---|
| alpha | D25+6.35° (c = 0.07 in ethanol) |
| Boiling point | 357.92°C (rough estimate) |
| Density | 1.48 |
| refractive index | 1.4359 (estimate) |
| Flash point | -3 °C |
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | solution (ethanol: 2-propanol 95:5) |
| pka | 11.91±0.70(Predicted) |
| color | White to off-white |
| biological source | Fusarium sp. (Fusarium asiaticum) |
| Merck | 13,10092 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/s3 |
| InChIKey | LINOMUASTDIRTM-QUKTVYMZNA-N |
| SMILES | [C@@]12(CO1)[C@@]1([H])[C@H](O)C[C@]2(C)[C@@]2(CO)[C@H](O)C(C(C)=C[C@@]2([H])O1)=O |&1:0,3,5,8,10,13,19,r| |
| LogP | -1.250 (est) |
| CAS DataBase Reference | 51481-10-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336-H371 | |||||||||
| Precautionary statements | P210-P305+P351+P338-P308+P311 | |||||||||
| Hazard Codes | T,Xn,F,Xi | |||||||||
| Risk Statements | 25-68/20/21/22-67-66-36-20/21/22-11-36/37/38 | |||||||||
| Safety Statements | 36/37/39-45-36-26-16-36/37-37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YD0167000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29329990 | |||||||||
| Hazardous Substances Data | 51481-10-8(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 i.p. in male, female mice (mg/kg): 70.0, 76.7 (Yoshizawa, Morooka) | |||||||||
| NFPA 704 |
|
DEOXYNIVALENOL price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D0156 | Deoxynivalenol | 51481-10-8 | 1MG | ₹10272.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1664 | Deoxynivalenol Ready Made Solution 1?mg/mL | 51481-10-8 | 1ML | ₹11664.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D0156 | Deoxynivalenol | 51481-10-8 | 5MG | ₹38677.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | CRM46911 | Deoxynivalenol solution certified reference material, 200?μg/mL in ethyl acetate: methanol (95:5), ampule of 1?mL | 51481-10-8 | 1ML | ₹12435.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 34124 | Deoxynivalenol solution 100?μg/mL in acetonitrile, analytical standard | 51481-10-8 | 2ML | ₹34739.6 | 2022-06-14 | Buy |
DEOXYNIVALENOL Chemical Properties,Uses,Production
Description
Vomitoxin or deoxynivalenol (DON) is one of the
trichothecenes (mycotoxins) which comprise a large
group (148 or more have been identified) of protein
synthesis inhibitors. These mycotoxins are also powerful
immunosuppressants which may predispose animals to
other diseases.
Vomitoxin is the most commonly found
trichothecene in moldy corn (maize), but a number of
other biologically active trichothecenes are produced by
species of the fungus Fusarium. These include nivalenol,
T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and
monoacetoxyscipenol (MAS). These mycotoxins are most
toxic when fed to swine and other monogastric animals
including humans. Poultry are generally more resistant
to trichothecenes than hogs, whereas T-2 toxin and DAS
appear to be more toxic to chickens than vomitoxin. Toxins
already present in corn at harvest may increase in stored
ear corn. Extended periods of warm, rainy, or damp
weather from flowering time onward promote infection
of corn by Fusarium species (1–7).
Chemical Properties
Off-White Solid
Uses
Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Deoxynivalenol exhibits cytotoxic activity in vivo via the ribotoxic stress response. Deoxynivalenol induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
General Description
Deoxynivalenol belongs to the class of type B trichothecene mycotoxins typically produced by the species of Fusarium genus. It is cytotoxic and is known to hinder the macromolecular synthesis.
DEOXYNIVALENOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21142 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32159 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10244 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19908 | 58 | Inquiry |
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