COLLISMYCIN A

COLLISMYCIN A Structure
CAS No.
158792-24-6
Chemical Name:
COLLISMYCIN A
Synonyms
Collismycin;COLLISMYCIN A;collisiomycin;(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime;[2,2'-Bipyridine]-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, [C(E)]-
CBNumber:
CB1355079
Molecular Formula:
C13H13N3O2S
Molecular Weight:
275.33
MOL File:
158792-24-6.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:16

COLLISMYCIN A Properties

Melting point 173-174 °C
Boiling point 450.7±45.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form A solid
pka 9.75±0.50(Predicted)

COLLISMYCIN A Chemical Properties,Uses,Production

Uses

Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues.

COLLISMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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COLLISMYCIN A Collismycin (E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime [2,2'-Bipyridine]-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, [C(E)]- collisiomycin 158792-24-6