2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- CAS No.
- 729589-58-6
- Chemical Name:
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- Synonyms
- 2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
- CBNumber:
- CB1382037
- Molecular Formula:
- C36H63N11O8
- Molecular Weight:
- 777.95
- MOL File:
- 729589-58-6.mol
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemical Properties,Uses,Production
Uses
2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.
General Description
2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.
Biochem/physiol Actions
2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
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| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | China | 2345 | 58 | Inquiry |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | China | 3581 | 58 | Inquiry |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | China | 3279 | 58 | Inquiry |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | China | 2944 | 58 | Inquiry |