Fmoc-Tyr(Me)-OH
- CAS No.
- 77128-72-4
- Chemical Name:
- Fmoc-Tyr(Me)-OH
- Synonyms
- Fmoc;FMOC-L-TYR(ME);FMOC-TYR(ME)-OH;FMOC-TYR(AL)-OH;FMOC-L-TYR(ME)-OH;Fmoc-4-Methoxy-Phe;FMOC-PHE(4-OME)-OH;FMOC-L-4-METHOXYPHE;Fmoc-L-4-MeO-Phe-OH;Methoxy phenylalanine
- CBNumber:
- CB1468274
- Molecular Formula:
- C25H23NO5
- Molecular Weight:
- 417.45
- MOL File:
- 77128-72-4.mol
- Modify Date:
- 2023/10/23 12:43:00
| Melting point | 161 °C |
|---|---|
| Boiling point | 647.8±55.0 °C(Predicted) |
| Density | 1.274±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| form | powder to crystal |
| pka | 2.97±0.10(Predicted) |
| color | White to Almost white |
| InChIKey | JYQODLWFOPCSCS-QHCPKHFHSA-N |
| SMILES | C(O)(=O)[C@H](CC1=CC=C(OC)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| CAS DataBase Reference | 77128-72-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | WGK 2 water endangering | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
Fmoc-Tyr(Me)-OH price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.52056 | Fmoc-Tyr(Me)-OH Novabiochem? | 77128-72-4 | 1G | ₹2000.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | CDS006940 | Fmoc-Tyr(Me)-OH AldrichCPR | 77128-72-4 | 10MG | ₹6170.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.52056 | Fmoc-Tyr(Me)-OH Novabiochem? | 77128-72-4 | 5G | ₹6460.01 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F1038 | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine | 77128-72-4 | 1G | ₹5300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F1038 | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-tyrosine | 77128-72-4 | 5G | ₹14500 | 2022-05-26 | Buy |
Fmoc-Tyr(Me)-OH Chemical Properties,Uses,Production
Description
Fmoc-Tyr(Me)-OH, also known as Fmoc-O-methyl-L-tyrosine, is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Chemical Properties
White to off-white powder
Synthesis
Fmoc-Tyr(Me)-OH, also known as Fmoc-Tyr(OMe)-OH, was obtained from Fmoc-Tyr(OMe)-OMe within 1h and was isolated following protocol 1 or 2 in 96% yield[1]. Under argon atmosphere, anhydrous THF (2.0 mL) was added to the protected amino acid Fmoc-Tyr(OMe)-OMe (0.12 mmol) and to MgI2 * (1.2 mmol). The suspension was heated in a sealed reactor using microwave irradiation at 120°C. A Na2S2O3 aqueous solution (0.1 M) was then added and the resulting homogeneous mixture was directly analysed by analytical HPLC and LC/MS. To isolate the product, two protocols could be applied:
Protocol 1: The crude material was purified by preparative HPLC.
Protocol 2: The crude material was extracted with AcOEt (x3). The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was diluted in H2O/EtOH and lyophilized.
References
[1] Berthet M, et al. MgI2 -Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies. Chemistry - A European Journal, 2015; 21: 11014-11016.
Fmoc-Tyr(Me)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Santo Righello Pvt. Ltd | 91-9885571757 | Hyderabad, India | 919 | 58 | Inquiry |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8617390183901 | China | 1106 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16209 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
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