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LY 171883

LY 171883 Structure
CAS No.
88107-10-2
Chemical Name:
LY 171883
Synonyms
S-1414;LY 171883;LY-171,833;TOMELUKAST;LY 171883 ISO 9001:2015 REACH;5-[4-4-ACETYL-3-HYDROXY-2-PROPYLPHENOXYBUTYL]-1H-TETRAZOLE;5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE;2’-hydroxy-3’-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)-acetophenon;1-(2-hydroxy-3-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)phenyl)-ethanon;1-[2-HYDROXY-3-PROPYL-4-[4-(1H-TETRAZOL-5-YL)BUTOXY]PHENYL]ETHANONE
CBNumber:
CB1666122
Molecular Formula:
C16H22N4O3
Molecular Weight:
318.37
MOL File:
88107-10-2.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:03:06

LY 171883 Properties

Melting point 117-119℃
Boiling point 553.0±60.0 °C(Predicted)
Density 1.220±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),
form White solid.
pka 5.02±0.10(Predicted)
color White
Stability Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
CAS DataBase Reference 88107-10-2

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Danger
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  KM5780800
NFPA 704
0
1 0

LY 171883 Chemical Properties,Uses,Production

Uses

LY 171883 is a selective leukotriene D4 antagonist.

Definition

ChEBI: A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti asthmatic activity.

Biological Activity

Selective, orally active leukotriene D 4 (LTD 4 ) antagonist; inhibits binding of [ 3 H]-LTD 4 to guinea pig lung membranes (K i = 0.63 μ M).? Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).

LY 171883 Preparation Products And Raw materials

Raw materials

Preparation Products

LY 171883 Suppliers

Global( 70)Suppliers
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Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
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Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24099 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +8619930503259 China 18423 58 Inquiry
Chengtian Fine Chemical Co., Ltd 18164098996 China 6679 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Wuhan Lvjing Fenghua Biotechnology Co., Ltd. 19972070065 China 6436 58 Inquiry
Dongguan Walixi Chemical Co., Ltd 0796-8612228 18664658771 China 4854 58 Inquiry
Focus Biomolecules 855-362-8721 United States 1284 58 Inquiry
TOMELUKAST LY-171,833 LY 171883 5-[4-4-ACETYL-3-HYDROXY-2-PROPYLPHENOXYBUTYL]-1H-TETRAZOLE 5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE 1-[2-HYDROXY-3-PROPYL-4-[4-(1H-TETRAZOL-5-YL)BUTOXY]PHENYL]ETHANONE 1-(2-hydroxy-3-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)phenyl)-ethanon 2’-hydroxy-3’-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)-acetophenon 5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole, Tomelukast S-1414 1-[2-hydroxy-3-propyl-4-[4-(2H-1,2,3,4-tetrazol-5-yl)butoxy]phenyl]ethanone 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone Ethanone, 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]- LY 171883 ISO 9001:2015 REACH 88107-10-2 C16H22N4O3 Prostanoid receptor and related