Denbufylline
- CAS No.
- 57076-71-8
- Chemical Name:
- Denbufylline
- Synonyms
- brl30892;DENBUFYLLINE;1,3-DI-N-BUTYL-7-(2'-OXOPROPYL)XANTHINE;7-Acetonyl-1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-2,6-dione;1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione;1H-Purine-2,6-dione, 1,3-dibutyl-3,7-dihydro-7-(2-oxopropyl)-
- CBNumber:
- CB1704523
- Molecular Formula:
- C16H24N4O3
- Molecular Weight:
- 320.39
- MOL File:
- 57076-71-8.mol
- Modify Date:
- 2023/5/4 17:34:40
| Melting point | 98-100°C |
|---|---|
| Boiling point | 514.8±56.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | -0.17±0.70(Predicted) |
| color | Off-White to Pale Beige |
| CAS DataBase Reference | 57076-71-8 |
Denbufylline Chemical Properties,Uses,Production
Description
Denbufylline, a xanthine derivative and PDE4 inhibitor, has effects such as vasodilatation of cerebral vessels (Willette et al., 1997) and potent activation of the hypothalamic–pituitary–adrenal axis. PDE4 is one of the cyclic adenosine monophosphate (cAMP)–specic phosphodiesterases whose tissue distribution is important in pathologies related to the central nervous and immune systems. In experimental animals, denbufylline increases adrenocorticotropic hormone (ACTH), circulating corticosterone, luteinizing hormone, corticotrophin-releasing hormone, and cAMP content of the hypothalamic tissue, but is without effect on arginine vasopressin (Kumari et al., 1997). Treves and Korczyn (1999) studied patients with AD, mixed dementia, and VaD treated with denbufylline. No signicant differences were found in comparison with placebo for the treatment of AD or VaD, although patients who received denbufylline tended to improve their cognitive scores.
Chemical Properties
White Solid
Uses
A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle apaillary muscle independently of its PDE inhibitory activity.
Denbufylline Preparation Products And Raw materials
Raw materials
Preparation Products
Denbufylline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |
| EMD Biosciences, Inc. | 858 450 5500 | United States | 6529 | 66 | Inquiry |
| VWR International | 800 932 5000 | United Kingdom | 6554 | 82 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| 2A PharmaChem USA | (630) 737-0988 | United States | 6148 | 39 | Inquiry |
| UK GREEN SCIENTIFIC CO.,LIMITED | +44(0)870 432 4488 | United Kingdom | 6107 | 47 | Inquiry |
| Waterstone Technology, LLC | 317 644 0862 | United States | 6801 | 30 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| CARBONE SCIENTIFIC CO.,LTD | +44(0)870 486 8629 | United Kingdom | 6682 | 30 | Inquiry |
Related articles
- Mechanism of action of Denbufylline
- Denbufylline, a xanthine derivative and PDE4 inhibitor, haseffects such as vasodilatation of cerebral vessels and potent activ....
- May 6，2022