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Lactoferrin

CAS No.: 146897-68-9

Chemical Name:: Lactoferrin

Synonyms: COLOSTRUM;MONL 03;AIDS096157;LACTOFERRIN;Lactoferricin;Lactoferricin B;Lactoferrin 90%+;Lactoferricin B25;LACTOFERRIN, HUMAN;LACTOFERRIN (BOVINE)

CBNumber:: CB1741610

Molecular Formula:: C141H224N46O29S3

Molecular Weight:: 3123.82

MOL File:: 146897-68-9.mol

Modify Date:: 2024/7/25 20:04:51

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Lactoferrin Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 1 mg/mL
form	powder
color	pink
PH	pH (20g/l, 25℃) : 5.2～7.2
Sequence	H-Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe-OH (Disulfide bond)

SAFETY

Risk and Safety Statements

Hazard Codes	B
Safety Statements	22-24/25
WGK Germany	3

Lactoferrin price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	L4040	Lactoferrin human recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)	146897-68-9	100MG	₹17995	2022-06-14	Buy
Sigma-Aldrich(India)	L-047	Lactoferrin (from bovine milk) certified reference material, pkg of 50?mg, Cerilliant?	146897-68-9	50MG	₹54170.9	2022-06-14	Buy

Product number	Packaging	Price	Buy
L4040	100MG	₹17995	Buy
L-047	50MG	₹54170.9	Buy

Lactoferrin Chemical Properties,Uses,Production

Description

Lactoferrin, a granule-associated glycoprotein, is a cationic protein with a high proportion of arginine and lysine at the N-terminal region, with two glycosylation and several iron-binding sites. Lactoferrin is highly antibacterial against both gram-positive and gram-negative bacteria at concentrations ranging from 3 to 50 μg/ml. It is believed that these lethal effects are due to a direct interaction of lactoferrin with the cell surface and subsequent disruption of normal permeability functions of the membrane, a so-called dissipation of proton motive force action (23). Similarly, expression of an antimicrobial tachyplesin gene from Asian horseshoe crabs led to antibacterial activity against Erwinia spp. in transgenic potato (24).

Uses

Lactoferrin was used in the fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. It was used in the determination of lactoferrin and immunoglobulin G in animal milks by new immunosensors.

Biological Activity

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Lactoferrin Preparation Products And Raw materials

Raw materials

Preparation Products

Lactoferrin Suppliers

Global( 144)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
Hebei Guanlang Biotechnology Co,.LTD	+86-19930503253; +8619930503252	China	5832	58	Inquiry
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.	+8615571922873	China	106	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
Shaanxi Franta Biotechnology Co., Ltd	+86-13082019107 +86-13082019107	China	225	58	Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	China	1142	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Guanlang Biotechnology Co,.LTD	58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shaanxi Franta Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55

Unlocking the Potential of Lactoferrin: Insights into Its Structure, Mechanism, and Multifaceted Applications in Chemistry
The molecular backbone of lactoferrin is characterized by its ability to tightly bind iron ions, a property central to many of....
Apr 10，2024

Exploring the therapeutic potential of lactoferrin: tissue regeneration, administration routes, and promise in cancer treatment
Lactoferrin shows significant promise in tissue regeneration, eye disease prevention, and potential cancer treatment.
Nov 23，2023

Lactoferrin:Activity and application studies
Lactoferrin, a prominent protein in milk, many other secretory fluids and white blood cells, is a monomeric, 80-kDa glycoprote....
Feb 10，2023

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