Nalmefene
- CAS No.
- 55096-26-9
- Chemical Name:
- Nalmefene
- Synonyms
- C08027;NALMEFENE;ORF-11676;nalmetrene;Nalmefene d3;Nalmefene-D7;NalMefene USP;6-Deoxo-6-methylenenaltrexone;6-desoxy-6-methylenenaltrexone;4,5α-Epoxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol
- CBNumber:
- CB1747788
- Molecular Formula:
- C21H25NO3
- Molecular Weight:
- 339.44
- MOL File:
- 55096-26-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/19 15:37:51
| Melting point | 182-185?C |
|---|---|
| Boiling point | 507.9±50.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | pKa 7.63(H2O) (Uncertain) |
| color | White to Off-White |
| CAS DataBase Reference | 55096-26-9 |
| NIST Chemistry Reference | Nalmefene(55096-26-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
Nalmefene Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.
Biological Functions
Nalmefene (Revex) is a long-acting injectable pure opioid antagonist recently introduced in the United States. It binds all opioid receptors and reverses the effects of opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism is slow and occurs via glucuronide conjugation to inactive metabolites. Its half-life of 11 hours is about 5 times that of naloxone. Indications include use in postoperative settings to reverse respiratory depression and in opioid overdose. Due to the long duration of action of nalmefene, however, naloxone may be preferred for treatment of overdose because it produces a shorter duration of withdrawal effects.
General Description
Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.
Nalmefene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Nanjing Lebang Pharmaceutical Technology Co., Ltd | 18860950986 | China | 518 | 58 | Inquiry |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 | China | 3239 | 55 | Inquiry |
| Taizhou Hikong Chemical Co., Ltd. | 0086-18967213045 | China | 52 | 50 | Inquiry |
| Amatek Scientific Co. Ltd. | 0512-56316828 | China | 28817 | 58 | Inquiry |
| TOSUN PHARM | 020-61855200 13326451905 | China | 7725 | 58 | Inquiry |
| LGC Science (Shanghai) Ltd. | 17717235263 | China | 11677 | 58 | Inquiry |
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