N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE

CAS No.: 127408-30-4

Chemical Name:: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE

Synonyms: Y-27152;Y 27152,Y27152;N-(Benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)-

CBNumber:: CB1837188

Molecular Formula:: C21H22N2O4

Molecular Weight:: 366.41

MOL File:: 127408-30-4.mol

Modify Date:: 2023/5/18 11:31:09

Request For Quotation

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Properties

Boiling point	513.4±60.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO
form	Powder
pka	13.18±0.60(Predicted)

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Chemical Properties,Uses,Production

Uses

Y-27152, is a prodrug of the Kir6 (KATP) channel opener. It has also shown to produce antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Biological Activity

Prodrug of the K ATP channel opener Y-26763 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide ). Inactive in vitro ; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. In vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Suppliers

Global( 35)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9618	58	Inquiry
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	China	6000	58	Inquiry
Finetech Industry Limited	027-87465837 19945049750	China	9612	58	Inquiry
Huayin Sample Biological Technology Co. LTD	13892502238	China	500	58	Inquiry
Hubei wei shi reagent group ltd., company	027-59105166 13125137732	China	2984	58	Inquiry
Anhui Xingzhou Pharmaceutical Technology Co. , Ltd.	17755122868 17755122868	China	9807	58	Inquiry
https://hanhongsci.com/	021-54306202 18917919676	China	29978	58	Inquiry
Nanjing Bic Biotechnology Co., Ltd	025-58906079 17352406906;	China	6929	58	Inquiry
BOC Sciences		USA	0	65	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Finetech Industry Limited	58
Nanjing Bicbiotechnology Co., Ltd	58
Finetech Industry Limited	58
Huayin Sample Biological Technology Co. LTD	58
Hubei wei shi reagent group ltd., company	58
Anhui Xingzhou Pharmaceutical Technology Co. , Ltd.	58
https://hanhongsci.com/	58
Nanjing Bic Biotechnology Co., Ltd	58
BOC Sciences	65

127408-30-4(N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE)Related Search:

6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-isopropoxybenzonitrile 3-CYANOBENZYLAMINE Benzenemethanamine, 2-(1-methylethoxy)- (9CI) 3-(methylaminomethyl)benzonitrile

3-M-TOLYL-DL-BETA-ALANINOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE 4-TERT-BUTOXYBENZONITRILE 2-(3-CYANO-PHENYL)ETHANOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

4-(2-hydroxyethoxy)benzonitrile D(-)-AC-ALPHA-PHENYLGLYCINOL 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI) (S)-1-Phenylethylhydroxylamine (S)-3-(1-Aminoethyl)benzonitrile

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N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Y-27152 N-(Benzyloxy)-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl)acetamide Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)- N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Y 27152,Y27152 127408-30-4 Potassium channel