N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

CAS No.: 127408-31-5

Chemical Name:: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

Synonyms: Y-26763;Y 26763,Y26763;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-

CBNumber:: CB7841565

Molecular Formula:: C14H16N2O4

Molecular Weight:: 276.29

MOL File:: 127408-31-5.mol

Modify Date:: 2024/7/2 8:55:17

Request For Quotation

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Properties

Boiling point	455.4±55.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble to 100 mM in 1eq. NaOH
form	Powder
pka	8.69±0.60(Predicted)
color	Off-white to yellow

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Chemical Properties,Uses,Production

Uses

Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.

Biological Activity

K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Suppliers

Global( 43)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9268	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24647	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
BOC Sciences	1-631-485-4226; 16314854226	United States	14059	65	Inquiry
CHEMICAL LAND21	82- 2 -783 - 8063	South Korea	6315	74	Inquiry
BIOTREND Chemicals AG	+41 44 805 76 76	Germany	1250	62	Inquiry
BIOTREND GmbH	+49-221-9498320	Germany	249	65	Inquiry
Beijing Seajet Scientific Inc	010-88597838,9569,8795	China	378	70	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58
Cayman Chemical Company	81
BOC Sciences	65
CHEMICAL LAND21	74
BIOTREND Chemicals AG	62
BIOTREND GmbH	65
Beijing Seajet Scientific Inc	70

127408-31-5(N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE)Related Search:

Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-27632 DIHYDROCHLORIDE Y27632 (hydrochloride)

3-M-TOLYL-DL-BETA-ALANINOL (S)-1-Phenylethylhydroxylamine 3-(methylaminomethyl)benzonitrile (S)-3-(1-Aminoethyl)benzonitrile 4-TERT-BUTOXYBENZONITRILE

3-CYANOBENZYLAMINE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-isopropoxybenzonitrile Benzenemethanamine, 2-(1-methylethoxy)- (9CI) 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI)

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE D(-)-AC-ALPHA-PHENYLGLYCINOL N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

chevron_left

1of4

chevron_right

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y-26763 Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy- Y 26763,Y26763 127408-31-5 C14H16N2O4 Potassium channel