16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- CAS No.
- 77017-20-0
- Chemical Name:
- 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- Synonyms
- BNKY015-BD01;Desonide Impurity M1;Budesonide Impurity 33;Budesonide Impurity 12;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
- CBNumber:
- CB1894903
- Molecular Formula:
- C23H28O6
- Molecular Weight:
- 400.46482
- MOL File:
- 77017-20-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/15 11:58:08
Melting point | 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4)) |
---|---|
Boiling point | 576.7±50.0 °C(Predicted) |
Density | 1.31±0.1 g/cm3(Predicted) |
solubility | soluble in Acetone, Dichloromethane |
pka | 11.92±0.70(Predicted) |
Water Solubility | 38.72mg/L at 25℃ |
LogP | 2.26 at 25℃ |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08,GHS07,GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H335-H361-H315-H319-H411 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Uses,Production
Uses
Intermediate in the preparation of antiinflammatory compounds.
Synthesis
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | China | 52 | 58 | Inquiry |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
CR Corporation Limited | +8613062833949 | China | 8647 | 58 | Inquiry |
Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | China | 376 | 58 | Inquiry |
Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | China | 129 | 58 | Inquiry |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | China | 5225 | 58 | Inquiry |
Shanghai Zerui Biotechnology Co., Ltd. | 021-54580889 18321124657 | China | 10614 | 58 | Inquiry |
Hubei Chenghai Chemical Co., Ltd | 18327245847 18327245847 | China | 9959 | 58 | Inquiry |
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