Doxorubicinone
- CAS No.
- 24385-10-2
- Chemical Name:
- Doxorubicinone
- Synonyms
- Ccris 7633;ADRIAMYCINONE;Doxorubicinone;Epirubicin aglycon;adriamycinaglycone;Epirubicin aglycone;Doxorubicin aglycone;Doxorubicinone-13C-D3;D2-N-Nitroso desmethyldoxycycline;Doxorubicin Hydrochloride EP Impurity D
- CBNumber:
- CB2121622
- Molecular Formula:
- C21H18O9
- Molecular Weight:
- 414.36
- MOL File:
- 24385-10-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/2/2 21:55:19
| Melting point | 223-225°C |
|---|---|
| Boiling point | 741.2±60.0 °C(Predicted) |
| Density | 1.671±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.45±0.60(Predicted) |
| color | Red to Very Dark Red |
| Stability | Light Sensitive |
| InChI | InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1 |
| InChIKey | IBZGBXXTIGCACK-CWKPULSASA-N |
| SMILES | C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O)=C3O)=CC=C1 |
| CAS DataBase Reference | 24385-10-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H311-H350-H340-H331-H360-H301 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501 | |||||||||
| HS Code | 29147000 | |||||||||
| NFPA 704 |
|
Doxorubicinone Chemical Properties,Uses,Production
Description
Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin . Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner. Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes. It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.
Chemical Properties
Red Solid
Uses
A metabolite of Doxorubicin (Dx).
General Description
Doxorubicinone (adriamycinone) is an aglycone. It is a metabolite of adriamycin converted in the body, and another metabolite is amycinol [1]. Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis.
References
[1] Emara S, et al. Effect of cyclodextrins on the stability of adriamycin, adriamycinol, adriamycinone and daunomycin. Talanta, 2008; 51: 359-364.
Doxorubicinone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| R&D Scientific Inc. | +12266000236 | Canada | 1422 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
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