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gracillin

gracillin Structure
CAS No.
19083-00-2
Chemical Name:
gracillin
Synonyms
Gracilline;DulcaMarinC;Gracillin-RM;LilioglycosideG;Gracillin 19083-00-2;Gracillin, 10 mM in DMSO;inhibit,Inhibitor,Gracillin;Diosgenin 3-O-β-gracillimatrioside;Diosgenin 3-O-beta-gracillimatrioside;Gracillin, 98%, from Dioscorea opposita Thunb.
CBNumber:
CB21352494
Molecular Formula:
C45H72O17
Molecular Weight:
885.04
MOL File:
19083-00-2.mol
Modify Date:
2025/4/17 18:22:24

gracillin Properties

Melting point 290-293℃ (DEC.)
Density 1.42
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO, methanol and pyridine
form powder
pka 12.78±0.70(Predicted)
color White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
HS Code  29329990

gracillin Chemical Properties,Uses,Production

Description

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM). Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L. It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid in mice.

Uses

Gracillin is a steroidal glycoside from the rhizomes of the family Dioscoreaceae with potential anti-proliferative effects.

gracillin Preparation Products And Raw materials

Raw materials

Preparation Products

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(25R)-3β-(2-O-α-L-Rhamnopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyloxy)spirosta-5-ene [(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-glucopyranosyl)-β-D-glucopyranoside [(25R)-Spirosta-5-ene-3β-yl]3-O-β-D-glucopyranosyl-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside Diosgenin 3-O-β-gracillimatrioside Gracilline Diosgenin 3-O-beta-gracillimatrioside DulcaMarinC LilioglycosideG Gracillin, 98%, from Dioscorea opposita Thunb. Gracillin 19083-00-2 β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]- (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-(((2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol inhibit,Inhibitor,Gracillin Gracillin-RM Gracillin, 10 mM in DMSO 19083-00-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract