ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Dioscin

Dioscin

CAS No.: 19057-60-4

Chemical Name:: Dioscin

Synonyms: ioscin;DIOSCIN;dioscine;DIOSCIN(P);Ccris 4123;DIOSCIN(RG);collettisideiii;Polyphyllin lll;Dioscin USP/EP/BP;Dioscin 19057-60-4

CBNumber:: CB2768036

Molecular Formula:: C45H72O16

Molecular Weight:: 869.06

MOL File:: 19057-60-4.mol

MSDS File:: SDS

Modify Date:: 2024/5/11 20:10:50

Request For Quotation

Dioscin Properties

Melting point	275～277℃
alpha	D13 -115° (c = 0.373 in ethanol)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	12?+-.0.70(Predicted)
form	Solid
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements	24/25
HS Code	29389090
Toxicity	mouse,LD50,subcutaneous,> 300mg/kg (300mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #91-271224,

Dioscin Chemical Properties,Uses,Production

Description

Dioscin is extracted from Dioscorea nipponica. Rhizoma Dioscoreae Nipponicae is the dry rhizome of this plant. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it can also be used externally to treat sore carbuncle swollen. Rhizoma Dioscoreae Nipponicae is commonly used in the northeast region, Shanxi province, and Shandong province of China.

Physical properties

Appearance: white powder. Solubility: insoluble in water, petroleum ether, and benzene; soluble in methanol, ethanol, and acetic acid; slightly soluble in acetone and amyl alcohol. Melting point: 294–296℃. Specific optical rotation: ?115° (c?=?0.373, ethanol).

History

Japanese scientists firstly reported and analyzed the structure of dioscin isolated from the saponins of Japanese Dioscoreaceae. V . However, the biological activities of dioscin have not attracted the interests of scientists until the late 1990s and the beginning of this century. It is now believed that dioscin may have therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, antiinflammatory, and antitumor effects. After the implementation of standardization of traditional Chinese medicine, dioscin as the quality control specification of Dioscorea nipponica Makino and other traditional Chinese medicine has attracted more attentions and researches. In China, dioscin tablets have been used to treat hyperlipidemia in the clinical practice. However, no corresponding drugs are available on the market in other countries. In addition, dioscin is also an important predecessor for synthesizing steroid hormones . Dioscorea nipponica Makino, which is used to extract dioscin, primarily comes from wild plants, whose resources are limited.

Indications

This drug was recorded in the national standards for chemical drugs, volume 5. Dioscin tablets, containing total dioscin, are used to treat coronary heart disease, coronary insufficiency, as well as control hyperlipidemia.

Pharmacology

Studies showed that compound preparations containing dioscin can increase coronary blood flow, reduce myocardial oxygen consumption, and protect myocardial ischemia and ischemia-reperfusion injury, which is beneficial for alleviating myocardial ischemia and angina. In addition, dioscin can regulate the lipid metabolism and improve hemodynamics. Dioscin can also prevent atherosclerosis by reducing serum total cholesterol, triglyceride, low-density lipoprotein, and oxidized lowdensity lipoprotein, reducing the whole blood viscosity and plasma viscosity at high and low shear rates, and relieving arterial wall lipid infiltration and plaque formation. Furthermore, dioscin can reduce liver fat deposition, which may be related to promoting cholesterol secretion metabolism.
It has also been reported that dioscin can induce the apoptosis of a variety of tumor cells, including gastric cancer cells, breast cancer cells, lung cancer cells, oral squamous cell carcinoma, and cervical cancer cells. The mechanisms are related to reducing the oxidative stress and inhibiting some cellular survival signaling pathways
Dioscin can induce antioxidant enzymes, lower blood lipids, improve insulin resistance, inhibit the inflammatory response, reduce the damage of alcoholic hepatitis, and decrease the hepatic injury induced by acetaminophen .

Dioscin Preparation Products And Raw materials

Raw materials

Preparation Products

Dehydroepiandrosterone

Dioscin Suppliers

Global( 297)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12462	58	Inquiry
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	China	326	58	Inquiry
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	China	3002	58	Inquiry
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	China	790	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
career henan chemical co	+86-0371-86658258 15093356674;	China	29902	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	China	8828	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Hebei Mojin Biotechnology Co., Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
BOC Sciences	58

Dioscin Spectrum

Dioscin(19057-60-4)MS

19057-60-4(Dioscin)Related Search:

Saponin POLYPHYLLIN B (RG) Chonglou Saponin II Matrine Esculin

Icariin POLYPHYLLIN E (RG) Paris saponin V palmitate POLYPHYLLIN D Chonglou Saponin VII

Polyphyllin VI Prosapogenin A 【dioscin】 27-Hydroxycholesterol PROTOGRACELLIN methyl protodioscin

Diosgenin glucoside Diosgenin Protodioscin

chevron_left

1of4

chevron_right

DIOSCIN beta-d-glucopyranoside,(3-beta,25r)-spirost-5-en-3-ylo-6-deoxy-alpha-l-mannop Dioscin(Collettiside III) Dioscin / Diosgenyl 2,4-Di-O-α-L-rhamnopyranosyl-β-D-glucopyranoside collettisideiii dioscine yranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl)-(1-4))- DIOSCIN(P) β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- (25R)-3β-[2-O,4-O-Bis(α-L-rhamnopyranosyl)-β-D-glucopyranosyloxy]spirosta-5-ene [(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside [(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-bis(α-L-rhamnopyranosyl)-β-D-glucopyranoside [(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-di-α-L-rhamnopyranosyl-β-D-glucopyranoside beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl o-6-deoxy-alpha-L-mannopyranosyl-(1-2)-o-(6-deoxy-alpha-L-mannopyranosyl-(1-4))- Ccris 4123 Dioscin (6ci,7ci,8ci) Diosgenin bis-alpha-L-rhamnopyranosyl)-(1-2 and 1-4)-beta-D-glucopyranoside DIOSCIN(RG) Dioscin, 98%, from Dioscorea opposita Thunb. Dioscin 19057-60-4 Dioscin Green Plants Extracts 19057-60-4 Dioscorea Nipponica Source COLLETTISIDE III; CCRIS 4123 Yam Extract Dioscin ioscin Dioscin USP/EP/BP Dioscin (CCRIS 4123) Polyphyllin lll (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol) (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol) 19057-60-4 C45H72O16 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Miscellaneous Natural Products Natural Plant Extract The group of Dioscin