Dioscin
- CAS No.
- 19057-60-4
- Chemical Name:
- Dioscin
- Synonyms
- ioscin;DIOSCIN;dioscine;DIOSCIN(P);Ccris 4123;Dioscin-RM;DIOSCIN(RG);collettisideiii;Polyphyllin lll;Dioscin USP/EP/BP
- CBNumber:
- CB2768036
- Molecular Formula:
- C45H72O16
- Molecular Weight:
- 869.06
- MOL File:
- 19057-60-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/7/10 14:15:12
| Melting point | 275～277℃ |
|---|---|
| alpha | D13 -115° (c = 0.373 in ethanol) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 12?+-.0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | VNONINPVFQTJOC-MRFMZFTMNA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Safety Statements | 24/25 |
| HS Code | 29389090 |
| Toxicity | mouse,LD50,subcutaneous,> 300mg/kg (300mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #91-271224, |
Dioscin Chemical Properties,Uses,Production
Description
Dioscin is extracted from Dioscorea nipponica. Rhizoma Dioscoreae Nipponicae is the dry rhizome of this plant. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it can also be used externally to treat sore carbuncle swollen. Rhizoma Dioscoreae Nipponicae is commonly used in the northeast region, Shanxi province, and Shandong province of China.
Physical properties
Appearance: white powder. Solubility: insoluble in water, petroleum ether, and benzene; soluble in methanol, ethanol, and acetic acid; slightly soluble in acetone and amyl alcohol. Melting point: 294–296℃. Specific optical rotation: ?115° (c?=?0.373, ethanol).
History
Japanese scientists firstly reported and analyzed the structure of dioscin isolated from the saponins of Japanese Dioscoreaceae. V . However, the biological activities of dioscin have not attracted the interests of scientists until the late 1990s and the beginning of this century. It is now believed that dioscin may have therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, antiinflammatory, and antitumor effects. After the implementation of standardization of traditional Chinese medicine, dioscin as the quality control specification of Dioscorea nipponica Makino and other traditional Chinese medicine has attracted more attentions and researches. In China, dioscin tablets have been used to treat hyperlipidemia in the clinical practice. However, no corresponding drugs are available on the market in other countries. In addition, dioscin is also an important predecessor for synthesizing steroid hormones . Dioscorea nipponica Makino, which is used to extract dioscin, primarily comes from wild plants, whose resources are limited.
Indications
This drug was recorded in the national standards for chemical drugs, volume 5. Dioscin tablets, containing total dioscin, are used to treat coronary heart disease, coronary insufficiency, as well as control hyperlipidemia.
Pharmacology
Studies showed that compound preparations containing dioscin can increase coronary blood flow, reduce myocardial oxygen consumption, and protect myocardial
ischemia and ischemia-reperfusion injury, which is beneficial for alleviating myocardial ischemia and angina. In addition, dioscin can regulate the lipid metabolism
and improve hemodynamics. Dioscin can also prevent atherosclerosis by reducing
serum total cholesterol, triglyceride, low-density lipoprotein, and oxidized lowdensity lipoprotein, reducing the whole blood viscosity and plasma viscosity at high
and low shear rates, and relieving arterial wall lipid infiltration and plaque formation. Furthermore, dioscin can reduce liver fat deposition, which may be related to
promoting cholesterol secretion metabolism.
It has also been reported that dioscin can induce the apoptosis of a variety of
tumor cells, including gastric cancer cells, breast cancer cells, lung cancer cells, oral
squamous cell carcinoma, and cervical cancer cells. The mechanisms are related to
reducing the oxidative stress and inhibiting some cellular survival signaling pathways
Dioscin can induce antioxidant enzymes, lower blood lipids, improve insulin
resistance, inhibit the inflammatory response, reduce the damage of alcoholic hepatitis, and decrease the hepatic injury induced by acetaminophen .
Dioscin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | China | 8773 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86-13288715578 | China | 12749 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3692 | 58 | Inquiry |
| Shaanxi Xianhe Biotech Co., Ltd | +8617709210191 | China | 885 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29855 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | China | 3751 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 1287 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd. | +86-0086-025-69916489 +86-18852044786 | China | 323 | 58 | Inquiry |
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