Alginic acid
| Melting point | 300 °C |
|---|---|
| storage temp. | Room Temperature |
| solubility | H2O: insoluble, but swells |
| form | Powder |
| color | White to pale yellow to beige |
| Odor | wh. to yel. fibrous powd., odorless, tasteless |
| Water Solubility | Insoluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,242 |
| LogP | -3.203 (est) |
| CAS DataBase Reference | 9005-32-7 |
| EPA Substance Registry System | Alginic acid (9005-32-7) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AZ5775000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 39131000 | |||||||||
| NFPA 704 |
|
Alginic acid price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A7003 | Alginic acid from brown algae | 9005-32-7 | 100G | ₹4351.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7003 | Alginic acid from brown algae | 9005-32-7 | 250G | ₹7999.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7003 | Alginic acid from brown algae | 9005-32-7 | 500G | ₹13791.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7003 | Alginic acid from brown algae | 9005-32-7 | 1KG | ₹25482.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0733 | Alginic Acid | 9005-32-7 | 25G | ₹2000 | 2022-05-26 | Buy |
Alginic acid Chemical Properties,Uses,Production
Chemical Properties
Alginic acid is a tasteless, practically odorless, white to yellowishwhite, fibrous powder.
Uses
algin (alginic acid) is used in cosmetic formulations as a thickener, stabilizer, and gelling agent. It is obtained from different varieties of brown seaweed.
Production Methods
Alginic acid is a hydrophilic colloid carbohydrate that occurs naturally in the cell walls and intercellular spaces of various species of brown seaweed (Phaeophyceae). The seaweed occurs widely throughout the world and is harvested, crushed, and treated with dilute alkali to extract the alginic acid.
Definition
A polysaccharide composed of β,d-mannuronic acid residues linked so that the carboxyl group of each unit is free, while the aldehyde group is shielded by a glycosidic linkage. It is a linear polymer of the mannuronic acid in the pyranose ring form.
Pharmaceutical Applications
Alginic acid is used in a variety of oral and topical pharmaceutical
formulations. In tablet and capsule formulations, alginic acid is used
as both a binder and disintegrating agent at concentrations of 1–5%
w/w. Alginic acid is widely used as a thickening and suspending
agent in a variety of pastes, creams, and gels; and as a stabilizing
agent for oil-in-water emulsions.
Alginic acid has been used to improve the stability of
levosimendan.
Therapeutically, alginic acid has been used as an antacid.In
combination with an H2-receptor antagonist, it has also been
utilized for the management of gastroesophageal reflux.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes
Safety
Alginic acid is widely used in food products and topical and oral
pharmaceutical formulations. It is generally regarded as a nontoxic
and nonirritant material, although excessive oral consumption may
be harmful. Inhalation of alginate dust may be an irritant and has
been associated with industrially related asthma in workers
involved in alginate production. However, it appears that the cases
of asthma were linked to exposure to unprocessed seaweed dust
rather than pure alginate dust. An acceptable daily intake of
alginic acid and its ammonium, calcium, potassium, and sodium
salts was not set by the WHO because the quantities used, and the
background levels in food, did not represent a hazard to health.
LD50 (rat, IP): 1.6 g/kg
storage
Alginic acid hydrolyzes slowly at warm temperatures producing a
material with a lower molecular weight and lower dispersion
viscosity.
Alginic acid dispersions are susceptible to microbial spoilage on
storage, which may result in some depolymerization and hence a
decrease in viscosity. Dispersions should therefore be preserved with
an antimicrobial preservative such as benzoic acid; potassium
sorbate; sodium benzoate; sorbic acid; or paraben. Concentrations
of 0.1–0.2% are usually used.
Alginic acid dispersions may be sterilized by autoclaving or
filtration through a 0.22 μm filter. Autoclaving may result in a
decrease in viscosity which can vary depending upon the nature of
any other substances present.
Alginic acid should be stored in a well-closed container in a cool,
dry place.
Purification Methods
To 5g of acid in 550mL water containing 2.8g KHCO3 are added 0.3mL of acetic acid and 5g potassium acetate. EtOH is added to make the solution to 25% (v/v) in EtOH, and any insoluble material is discarded. Further addition of EtOH, to 37% (v/v), precipitated alginic acid. Collect the acid and dry it in vacuo. [Pal & Schubert J Am Chem Soc 84 4384 1962.]
Incompatibilities
Incompatible with strong oxidizing agents; alginic acid forms insoluble salts in the presence of alkaline earth metals and group III metals with the exception of magnesium.
Regulatory Status
GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.
Alginic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Snap Natural And Alginate Products Pvt Ltd | +91-9842322117 +91-9821145685 | Tamil Nadu, India | 6 | 58 | Inquiry |
| Amit Hydrocolloids | +91-2261540304 +91-2261540303 | Maharashtra, India | 8 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Snap Natural And Alginate Products Pvt Ltd | 58 |
| Amit Hydrocolloids | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
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