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W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE Structure
CAS No.
61714-27-0
Chemical Name:
W-7 HYDROCHLORIDE
Synonyms
W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7 hydrochloride, 10 mM in DMSO;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
CBNumber:
CB2182197
Molecular Formula:
C16H22Cl2N2O2S
Molecular Weight:
377.33
MOL File:
61714-27-0.mol
Modify Date:
2025/1/27 9:38:02
Request For Quotation

W-7 HYDROCHLORIDE Properties

Melting point 220-222 °C
storage temp. -20°C
solubility methanol: 25 mg/mL, clear, colorless
form Off-white crystalline solid
color White to Off-White
BRN 6030174
CAS DataBase Reference 61714-27-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
RTECS  QK0786000
F  3-10
HS Code  2935909099

W-7 HYDROCHLORIDE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A3281 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride 61714-27-0 25MG ₹14592.1 2022-06-14 Buy
Sigma-Aldrich(India) A3281 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride 61714-27-0 100MG ₹40712.83 2022-06-14 Buy
Sigma-Aldrich(India) A3281 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride 61714-27-0 250MG ₹87996.43 2022-06-14 Buy
Sigma-Aldrich(India) 681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC?? = 51 μM) and Ca2+-calmodulin-dependent phosphodies 61714-27-0 10MG ₹14260 2022-06-14 Buy
TCI Chemicals (India) A2409 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride 61714-27-0 100MG ₹8600 2022-05-26 Buy
Product number Packaging Price Buy
A3281 25MG ₹14592.1 Buy
A3281 100MG ₹40712.83 Buy
A3281 250MG ₹87996.43 Buy
681629 10MG ₹14260 Buy
A2409 100MG ₹8600 Buy

W-7 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).

Chemical Properties

White Crystalline Solid

Uses

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

General Description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).

Biological Activity

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

W-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

W-7 HYDROCHLORIDE Suppliers

Global( 143)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30231 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 +8617705817739 China 52849 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49734 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49984 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
GIHI CHEMICALS CO.,LIMITED 58
Aladdin Scientific 58

W-7 HYDROCHLORIDE Spectrum

W-7 HYDROCHLORIDE(61714-27-0)IRW-7 HYDROCHLORIDE(61714-27-0)Raman

61714-27-0(W-7 HYDROCHLORIDE)Related Search:

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OMEGA-7 HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE W-7 W-7 HYDROCHLORIDE N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7 ulfonaMide W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem CS-1064 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride > SKL179 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor W-7 hydrochloride, 10 mM in DMSO 61714-27-0 C16H21ClN2O2SClH Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators Calcium signaling