PIK-93
- CAS No.
- 593960-11-3
- Chemical Name:
- PIK-93
- Synonyms
- PI-93;PIK 93;CS-426;PIK-93,PIK93;Shokat PI3K/PIK-93;PIK-93;PIK 93;PIK93;PI 3,4-K inhibitor, PIK-93;PI 3-4-K inhibitor PIK-93 PIK93;PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem;N-[5-[4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methylthiazol-2-yl]acetamide
- CBNumber:
- CB22484673
- Molecular Formula:
- C14H16ClN3O4S2
- Molecular Weight:
- 389.88
- MOL File:
- 593960-11-3.mol
- Modify Date:
- 2023/5/18 11:31:15
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| InChIKey | JFVNFXCESCXMBC-UHFFFAOYSA-N |
| CAS DataBase Reference | 593960-11-3 |
PIK-93 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0546 | PIK93 ≥98% (HPLC) | 593960-11-3 | 5MG | ₹12394.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0546 | PIK93 ≥98% (HPLC) | 593960-11-3 | 25MG | ₹50076.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 528122 | PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is | 593960-11-3 | 5MG | ₹23839.99 | 2022-06-14 | Buy |
PIK-93 Chemical Properties,Uses,Production
Description
PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC50 = 19 nM). It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells. It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.
Uses
PIK 93 is a PI3Kγ and PI4KIIIβ inhibitor.
Enzyme inhibitor
This potent and selective PI3Kγ/PI4KIIIβ inhibitor (FW = 389.88; CAS 593960-11-3; Solubility (25°C): 78 mg/mL DMSO, <1 mg/mL Water), also known as N-[5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4- methylthiazol-2-yl]acetamide, impairs actin filament consolidation and stability at the leading edge in cells treated with N-formyl-Met-Leu-Phe as well as ceramide transport between ER and Golgi compartments. The inhibition of PI3K by PIK-93, LY294002, or wortmannin decreased carbachol-induced translocation of TRPC6 to the plasma membrane and carbachol-induced net Ca2+ entry into T6.11 cells. PIK-93 inhibits both poliovirus (PV) and hepatitis C virus (HCV) replication, with EC50 values of 0.14 μM and 1.9 μM, respectively. Targets: PI3Kγ, IC50 = 16 nM; PI4KIIIβ, IC50 = 19 nM; PI3Kα, IC50 = 39 nM; PI3Kδ, IC50 = 0.12 μM; and PI3Kβ, IC50 = 0.59 μM.
PIK-93 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |