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PIK-294
![PIK-294 Structure](CAS/GIF/900185-02-6.gif)
- CAS No.
- 900185-02-6
- Chemical Name:
- PIK-294
- Synonyms
- CS-537;PIK-294;PIK294;PIK 294;AR-12 OSU-03012;PIK-294 USP/EP/BP;2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)q;2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one;2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone;4(3H)-Quinazolinone, 2-[[4-aMino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]Methyl]-5-Methyl-3-(2-Methylphenyl)-
- CBNumber:
- CB12537813
- Molecular Formula:
- C28H23N7O2
- Molecular Weight:
- 489.53
- MOL File:
- 900185-02-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:03
Boiling point | 790.4±70.0 °C(Predicted) |
---|---|
Density | 1.43 |
storage temp. | -20°C |
solubility | ≥24.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
pka | 8.95±0.10(Predicted) |
form | powder |
color | white to beige |
CAS DataBase Reference | 900185-02-6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P301+P310+P330 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
NFPA 704 |
|
PIK-294 price More Price(2)
PIK-294 Chemical Properties,Uses,Production
Uses
PIK-294 is a derivative of PIK-293 (P437700) and a highly selective inhibitor of p110δ which is an isoform of phosphoinositide 3-kinase (PI3K).
Biochem/physiol Actions
PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110δ with an IC50 value of 10 nM compared to IC50 values of 10 μM, 490 nM and 160 nM for PI3Kα/β/γ, respectively. PIK-294 has been used to help distinguish the unique roles of the various PI3-K isoforms. For example, in a study of CXCL8-induced neutrophil migration, PIK-294 inhibited both chemokinetic and chemotactic CXCL8-induced migration whereas PI3Kγ inhibitor AS-605240 markedly reduced CXCL8 induced chemokinetic migration but had no effect on CXCL8 induced chemotactic migration.
PIK-294 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 104)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
900185-02-6(PIK-294)Related Search:
4(3H)-Quinazolinone, 2-[[4-aMino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]Methyl]-5-Methyl-3-(2-Methylphenyl)-
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)q
PIK-294
2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
PIK294;PIK 294
CS-537
PIK-294 USP/EP/BP
AR-12 OSU-03012
900185-02-6
Inhibitors
Akt
mTOR
PI3K