Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PDK-1 inhibitors >OSU-03012

OSU-03012

OSU-03012 Structure
CAS No.
742112-33-0
Chemical Name:
OSU-03012
Synonyms
AR-12;CS-1848;N/AAR-12;OSU-03012;OSU-03012, >=98%;OSU-03012 (AR-12);OSU-03012 USP/EP/BP;PDK1 inhibitor AR-12;Osu03012, 10 mM in DMSO;N/AAR-12; OSU03012; OSU 03012
CBNumber:
CB22501006
Molecular Formula:
C26H19F3N4O
Molecular Weight:
460.45
MOL File:
742112-33-0.mol
MSDS File:
SDS
Modify Date:
2024/11/19 23:02:33
Request For Quotation

OSU-03012 Properties

storage temp. Store at -20°C
solubility ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
color White to off-white
CAS DataBase Reference 742112-33-0

OSU-03012 Chemical Properties,Uses,Production

Description

Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

Uses

OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.

Definition

ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.

OSU-03012 Preparation Products And Raw materials

Raw materials

Preparation Products

OSU-03012 Suppliers

Global( 140)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32222 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22855 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

OSU-03012 Spectrum

OSU-03012(742112-33-0)1HNMR

742112-33-0(OSU-03012)Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER L-Alanyl-L-Glutamine impurity 25
2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) Sildenafil citrate BX-912 Axitinib
Dasatinib BX-795 BEZ235 (NVP-BEZ235, Dactolisib)
chevron_left

1of3

chevron_right
OSU-03012, >=98% OSU-03012 (AR-12) 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 N/AAR-12 OSU-03012 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012 CS-1848 N/AAR-12; OSU03012; OSU 03012 Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- OSU-03012 USP/EP/BP AR-12 Osu-03012|||Osu 03012|||AR-12 PDK1 inhibitor AR-12 Osu03012, 10 mM in DMSO 742112-33-0 C26H19F3N4O Inhibitors Inhibitor of phosphoinositide-dependent kinase-1. Akt mTOR PI3K