Dexrazoxane
- CAS No.
- 24584-09-6
- Chemical Name:
- Dexrazoxane
- Synonyms
- adr529;cardioxane;DEXRAZOXANE;DEXTRAZOXANE;(S)-ICRF-187;DEXTRORAZOXANE;Dexrazoxane>Right razoxane;(+)-dexrazoxane;Dexrazoxane, >=99%
- CBNumber:
- CB2251448
- Molecular Formula:
- C11H16N4O4
- Molecular Weight:
- 268.27
- MOL File:
- 24584-09-6.mol
- Modify Date:
- 2024/4/3 17:07:09
| Melting point | 194-196°C |
|---|---|
| alpha | D +11.35° (c = 5 in DMF) |
| Boiling point | 531.5±50.0 °C(Predicted) |
| Density | 1.333±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| pka | 2.1(at 25℃) |
| color | white to off-white |
| Merck | 14,8123 |
| InChIKey | BMKDZUISNHGIBY-ZETCQYMHSA-N |
| CAS DataBase Reference | 24584-09-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TL6390000 | |||||||||
| HS Code | 2933.59.9500 | |||||||||
| NFPA 704 |
|
Dexrazoxane price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D1446 | Dexrazoxane ≥95% (HPLC) | 24584-09-6 | 5MG | ₹10857.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1446 | Dexrazoxane ≥95% (HPLC) | 24584-09-6 | 25MG | ₹42325.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05587 | Dexrazoxane analytical standard | 24584-09-6 | 25MG | ₹7869.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4227 | Dexrazoxane | 24584-09-6 | 100MG | ₹5700 | 2022-05-26 | Buy |
Dexrazoxane Chemical Properties,Uses,Production
Description
Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
Uses
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
General Description
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Biological Activity
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Dexrazoxane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| MSN LABORATORIES PRIVATE LTD | +91 40 30438600 | New Delhi, India | 230 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Laurus Labs Ltd | 58 |
| Gland Pharma Ltd | 58 |
| AKASH PHARMA EXPORTS | 58 |
| MSN LABORATORIES PRIVATE LTD | 58 |
| GLAND PHARMA LTD | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
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