BLASTICIDIN S
- CAS No.
- 2079-00-7
- Chemical Name:
- BLASTICIDIN S
- Synonyms
- blasticidin;bab;Blas;babs;Blaes;bcs-3;toabla-s;cytovirin;bcs-3、bla-s;blastizidin
- CBNumber:
- CB2269508
- Molecular Formula:
- C17H26N8O5
- Molecular Weight:
- 422.45
- MOL File:
- 2079-00-7.mol
- Modify Date:
- 2024/3/16 16:21:40
| Melting point | 235°C |
|---|---|
| Boiling point | 539.06°C (rough estimate) |
| alpha | D11 +108.4° (water) |
| Density | 1.1690 (rough estimate) |
| vapor pressure | Low |
| refractive index | 1.6910 (estimate) |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble |
| form | A solid |
| pka | 2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases) |
| Water Solubility | >30 g l-1(20 °C) |
| Stability | Incompatible with strong oxidizing agents. |
| EPA Substance Registry System | Blasticidin S (2079-00-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 24/25-36/37-45 | |||||||||
| RIDADR | 3172 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 i.v. in mice: 2.82 mg/kg (Takeuchi) | |||||||||
| NFPA 704 |
|
BLASTICIDIN S Chemical Properties,Uses,Production
Description
Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).
Uses
Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.
Production Methods
Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).
Definition
ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.
General Description
Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.
Pharmacology
Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.
Metabolic pathway
Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.
Metabolism
3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT50 < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).
BLASTICIDIN S Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | China | 10814 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Nantong Zhonghe Chemical New Materials Co., Ltd | 13003551299 13003551299 | China | 7567 | 58 | Inquiry |
| JIANGSU BSECHEM CHEMICAL TECHNOLOGY Co., Ltd | 15651337098 | China | 3002 | 58 | Inquiry |
| Billiken International Holding Ltd | +86-755-26805382 | China | 277 | 30 | Inquiry |
| Lynnchem | 86-(0)29-85992781 17792393971 | China | 4587 | 58 | Inquiry |
| Shanghai Mingrui Biotechnology Co., Ltd. | 021-64049450 | CHINA | 2 | 58 | Inquiry |
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